Remeglurant
Remeglurant (MRZ-8456) acts as a selective, orally active and allosteric antagonist of the mGlu5 receptor, with an IC50 of 13 nM. Remeglurant (MRZ-8456) can be used in the research for dyskinesia in Parkinson’s disease (PD).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1309783-00-3
- Formule: C17H15BrN4O
- Masse moléculaire:371.23
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
mGluR 5 13 nM (IC50) |
Chemical Information
-
CAS No. 1309783-00-3
-
Masse moléculaire 371.23
-
Formule C17H15BrN4O
-
SMILES
O=C(N1[C@@H](C2=C(CC1)C=CC=C2)C)C3=NN4C=C(C=NC4=C3)Br
-
Synonyms
MRZ-8456
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Pamela R Westmark, et al. Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056. Neurobiol Dis. 2018 Nov:119:190-198. [Content Brief]
[2]. Philippe Huot, et al. Targeting metabotropic glutamate receptors for the treatment of Parkinson's disease. Neurodegener Dis Manag. 2023 Aug;13(4):203-206. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Remeglurant Related Classifications
HY-118238 Related Classifications
Powered by Bioz