RU28362
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- CAS No.: 74915-64-3
- Formule: C23H28O3
- Masse moléculaire:352.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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BNIP3 |
RU28362 (0.1, 1, 5, 10 nM; 72 h) increases the Bnip3 mRNA levels in a dose-dependent manner after 72 h in neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary cortical neurons
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Concentration:0.1, 1.0, 5.0, 10.0 nM
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Incubation Time:48, 72 h
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Result:Significantly increased the Bnip3 mRNA levels in a dose-dependent manner after 72 h, Bnip3 mRNA levels were not changed after treatment with RU28362 for 48 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:250-350 g, adult male Sprague-Dawley rats[2]
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Dosage:150 µg/kg
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Administration:I.p.; 60 min before exposure to a 15-min period of restraint stress
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Result:Inhibited adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland.
Chemical Information
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CAS No. 74915-64-3
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Masse moléculaire 352.47
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Formule C23H28O3
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SMILES
O=C1C=C[C@@]2([C@]3([C@H](C[C@@]4([C@@](O)(CC[C@]4([C@@]3(C=C(C2=C1)C)[H])[H])C#CC)C)O)[H])C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144(2):482-94. [Content Brief]
[2]. Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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