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Cat. No.: HY-126803

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Saquayamycin B

Saquayamycin B (compound 3) is a new angucycline antibiotic. Saquayamycin B has antitumor activities against a human lung (H-460) and a human breast cancer cell line (MCF-7) with GI₅₀ values of 12.2 and 15.2 µM respectively .

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CAS No.: 99260-67-0
Formule: C₄₃H₄₈O₁₆
Masse moléculaire:820.83

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Saquayamycin B Chemical Structure

CAS No.: 99260-67-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
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Bioz

Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	GI₅₀	15.2 μM Compound: 3	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 18666798]
MCF7	GI₅₀	15.2 μmol Compound: 3	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 18666798]
NCI-H460	GI₅₀	12.2 μM Compound: 3	Cytotoxicity against human H460 cells after 48 hrs by SRB assay Cytotoxicity against human H460 cells after 48 hrs by SRB assay	[PMID: 18666798]
NCI-H460	GI₅₀	12.2 μmol Compound: 3	Cytotoxicity against human H460 cells after 48 hrs by SRB assay Cytotoxicity against human H460 cells after 48 hrs by SRB assay	[PMID: 18666798]
NCI-H460	GI₅₀	3.929 μM Compound: 8	Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay	[PMID: 22758660]
PC-3	GI₅₀	0.07454 μM Compound: 8	Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay	[PMID: 22758660]

Chemical Information

CAS No. 99260-67-0
Masse moléculaire 820.83
Formule C₄₃H₄₈O₁₆
SMILES

O=C1C[C@@](O[C@H]2CC[C@H](O[C@H]3C=CC([C@H](C)O3)=O)[C@H](C)O2)(C)C[C@]4(O)[C@@]1(O)C(C(C5=CC=C([C@H]6C[C@@]7([H])O[C@](CC([C@H](C)O8)=O)([H])[C@]8([H])O[C@]7([H])[C@@H](C)O6)C(O)=C5C9=O)=O)=C9C=C4
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces sp.
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mohamed S Abdelfattah, et al. Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002. J Nat Prod. 2008 Sep;71(9):1569-73. [Content Brief]

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Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Saquayamycin B

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Saquayamycin B Related Classifications

HY-126803 Related Classifications