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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Synonyms: CB1-IN-1
Target:
Domaines de recherche:
BPRCB1184 (CB1-IN-1) is a peripherally restricted 1-type cannabinoid receptor (CB1) antagonist, whose activity is associated with the regulation of obesity-related endocannabinoid system. BPRCB1184 regulates the activity of the endocannabinoid system, promotes lipid mobilization, reduces triglyceride storage, improves glucose metabolism, decreases food intake and body weight, while enhances insulin resistance and improves blood lipid levels. BPRCB1184 can be used in obesity-related research .
Cat. No.: HY-129396
CAS No.: 1439268-65-1
Target:
Domaines de recherche:
LA1011 is a heat shock protein (Hsps) co-inducer that selectively enhances heat shock-induced Hsp70, Hsp40, and Hsp27 expression. LA1011 exhibits neuroprotective effects in APPxPS1 transgenic Alzheimer's disease mice, preventing hippocampal neuronal loss, reducing tau pathology and neurofibrillary tangle accumulation in the hippocampus, decreasing amyloid plaque formation in the hippocampus, and increasing dendritic spine density in hippocampal CA1. LA1011 can be used for research on Alzheimer's disease .
Cat. No.: HY-13315R
CAS No.: 151767-02-1
Synonyms: MK0476 (Standard)
Domaines de recherche:
Montelukast (sodium) (Standard) is the analytical standard of Montelukast (sodium). This product is intended for research and analytical applications. Montelukast sodium (MK0476) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast sodium decreases eosinophil infiltration into the asthmatic airways. Montelukast sodium can also be used for COVID-19 research .
Synonyms: (-)-Deguelin (Standard); (-)-cis-Deguelin (Standard)
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Isoflavanones Derris trifoliata Lour. Extract
Target:
Cat. No.: HY-137135
CAS No.: 28874-45-5
Target:
Drug Derivative Reactive Oxygen Species (ROS) Mitochondrial Metabolism Lactate Dehydrogenase Apoptosis Keap1-Nrf2 Heme Oxygenase (HO) Glutathione Peroxidase MMP Phosphatase
Domaines de recherche:
Cantharidic acid is a Cantharidin (HY-N0209) analog, anticancer agent, and selective Ser/thr phosphatase 1 and 2A inhibitor. Cantharidic acid induces ROS, Mitochondrial dysfunction, LDH release, cell cycle arrest, and Apoptosis. Cantharidic acid decreases Nrf2, HO-1, and GPX4, and reduces PCNA, MMP2, and MMP9. Cantharidic acid can be used in research on colorectal cancer, hepatocellular carcinoma, oral squamous cell carcinoma, and adenocarcinoma .
Cat. No.: HY-145290
CAS No.: 2968315-02-6
Target:
Domaines de recherche:
CPT-Se3, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT–Se3 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se3 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC50= 2.19-4.7 μM) .
Cat. No.: HY-145291
CAS No.: 2968315-03-7
Target:
Domaines de recherche:
CPT-Se4, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC50= 2.54-6.4 μM) .
Cat. No.: HY-146261
CAS No.: 2411548-90-6
Domaines de recherche:
HI5 is a potent tublin and IDO inhibitor, with an IC50 value of 70 nM in HeLa cells. HI5 inhibit IDO expression and decrease kynurenine production, leading to stimulating T cells activation and proliferation. HI5 can inhibit tubulin polymerization and cell migration, cause G2/M phase arrest, and induce apoptosis via the mitochondrial dependent apoptosis pathway and cause reactive oxidative stress generation in HeLa cells. HI5 can be used for researching anticancer .
Cat. No.: HY-147266
Pureté: 95.83%
Synonyms: VIR-2218 sodium
Target:
Domaines de recherche:
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .
Cat. No.: HY-147266A
CAS No.: 2648009-64-5
Synonyms: VIR-2218
Target:
Domaines de recherche:
Elebsiran (VIR-2218) is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran can be used for the study of chronic HBV/HDV infections .
Cat. No.: HY-150364A
CAS No.: 2921918-19-4
Synonyms: RGLS8429 sodium; RG1015 sodium
Target:
Domaines de recherche:
Farabursen sodium (RGLS8429 sodium; RG1015 sodium) is a miR-17 inhibitor. Farabursen sodium inhibits the function of the miR-17 family, relieves the inhibitory effect on miR-17 target genes including PKD1 and PKD2, and increases the level of PC1/2. Farabursen sodium slows the growth of renal cysts, reduces the ratio of kidney weight to body weight, and decreases the cyst index and proliferation index. Farabursen sodium is applicable to research related to autosomal dominant polycystic kidney disease .
Cat. No.: HY-151984
CAS No.: 2872677-61-5
CDK9-IN-22 is a potent CDK9 inhibitor with IC50s of 10.4, 876.2 nM for CDK9, CDK, respectively. CDK9-IN-22 induces apoptosis and cell cycle arrests at G2/M phase. CDK9-IN-22 decreases the expression of p-RNAPII (S2) and CDK9 protein. CDK9-IN-22 shows antiproliferative and aiti-tumor activity .
Domaines de recherche:
APG-2449 is an orally active inhibitor for BCL-2 and multikinase (ALK/FAK/ROS1) with potent antitumor activities. APG-2449 reduces cell viability and enhances apoptosis in acute myeloid leukemia cells in vitro. APG-2449 decreases activation of FAK and its downstream effectors. APG-2449 can be studied in research for mesothelioma tumor, non-small cell lung cancer, ovarian cancer, hematologic and solid malignancies .
Cat. No.: HY-155245
CAS No.: 2911646-14-3
Target:
Domaines de recherche:
A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation .
Cat. No.: HY-155726
CAS No.: 444792-16-9
Cy-FBP/SBPase-IN-1 (compound S5) is a Cy-FBP/SBPase inhibitor, which is an important regulatory enzyme in cyanobacterial photosynthesis. Thus Cy-FBP/SBPase-IN-1 inhibits Calvin cycle and photosystem, and decreases photosynthetic efficiency in cyanobacterial photosynthesis. Cy-FBP/SBPase-IN-1 potently inhibits the growth of cyanobacteria, as well as Synechocystis sp.PCC6803. Cy-FBP/SBPase-IN-1 shows safety profile in human-derived cells and zebrafish models .
Cat. No.: HY-155909
CAS No.: 92451-01-9
Synonyms: mPEG3400-SC; mPEG3400-Succinimidyl ester
Domaines de recherche:
m-PEG3400-NHS ester (mPEG3400-SC; mPEG3400-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG3400‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG3400-NHS ester can be used in drug delivery-related research .
Synonyms: mPEG1000-SC; mPEG1000-Succinimidyl ester
Domaines de recherche:
m-PEG1000-NHS ester (mPEG1000-SC; mPEG1000-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG1000‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG1000-NHS ester can be used in drug delivery-related research .
Cat. No.: HY-155909B
CAS No.: 92451-01-9
Synonyms: mPEG550-SC; mPEG550-Succinimidyl ester
Domaines de recherche:
m-PEG550-NHS ester (mPEG550-SC; mPEG550-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG550‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG550-NHS ester can be used in drug delivery-related research .
Synonyms: mPEG350-SC; mPEG350-Succinimidyl ester
Domaines de recherche:
m-PEG350-NHS ester (mPEG350-SC; mPEG350-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG350‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG350-NHS ester can be used in drug delivery-related research .
Cat. No.: HY-159938
p38α inhibitor 6 (compound 19) is a p38α inhibitor with the IC50 of 0.68 μM. p38α inhibitor 6 induces cell apoptosis and arrests cell cycle at G0 and G2/M phase. p38α inhibitor 6 decreases the TNF-α concentration as well as increased the expression of tumor suppressor gene p53, Bax/BCL-2 ratio and caspase 3/7 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
