LA1011
LA1011 is a heat shock protein (Hsps) co-inducer that selectively enhances heat shock-induced Hsp70, Hsp40, and Hsp27 expression. LA1011 exhibits neuroprotective effects in APPxPS1 transgenic Alzheimer's disease mice, preventing hippocampal neuronal loss, reducing tau pathology and neurofibrillary tangle accumulation in the hippocampus, decreasing amyloid plaque formation in the hippocampus, and increasing dendritic spine density in hippocampal CA1. LA1011 can be used for research on Alzheimer's disease.
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- CAS No.: 1439268-65-1
- Formule: C25H36Cl2F3N3O4
- Masse moléculaire:570.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
IC50 & Target
[1]|
HSP70 |
HSP40 |
In Vitro
LA1011 (5-10 µM) does not alter yeast Hsp90 ATPase activity[1].
LA1011 (5 µM; 30 min-17 h) co-induced Hsp70 promoter-driven YFP expression in SH-SY5Y-pHsp70-YFP cells under 42°C heat shock conditions[1].
LA1011 (5 µM; 1-16 h) selectively co-induces Hsp27, Hsp40, and Hsp70 in heat-shocked SH-SY5Y cells without altering Hsp levels under non-stressed conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:5 µM
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Incubation Time:1 h (42°C heat shock); 16 h (37°C recovery)
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Result:Increased Hsp27, Hsp40, and Hsp70 levels under heat shock.
Did not alter Hsp27, Hsp40, Hsp70, Hsp60, or Hsp90 levels without heat shock.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B6C3-Tg (APPswe/PS1dE9)85Dbo/Mmjax (C57BL/6 genetic background; male; 3 months old at start)[1]
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Dosage:3 mg/kg
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Administration:i.p.; once daily; 6 months
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Result:Improved spatial learning and memory in the Morris water maze.
Required less time to find the platform than transgenic saline controls.
Prevented loss of hippocampal neurons.
Decreased the number of abnormally accumulated neurofibrillary tangles in the hippocampus to the level found in wild-type mice.
Increased dendritic spine number in hippocampal CA1 compared with transgenic saline controls.
Decreased amyloid plaque formation in the hippocampus.
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Animal Model:wild-type C57BL/6 (male; 3 months old at start)[1]
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Dosage:3 mg/kg
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Administration:i.p.; once daily; 6 months
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Result:Improved memory performance in the Morris water maze.
Required less time to complete the task than wild-type saline controls.
Did not affect dendritic spine number in wild-type mice.
Chemical Information
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CAS No. 1439268-65-1
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Masse moléculaire 570.47
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Formule C25H36Cl2F3N3O4
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SMILES
O=C(C1=C(CCN(C)C)N(C)C(CCN(C)C)=C(C1C2=CC=C(C(F)(F)F)C=C2)C(OC)=O)OC.Cl.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LA1011 Related Classifications
HY-129396 Related Classifications
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