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Cat. No.: HY-125677

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SHetA2

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SHetA2 is a derivative of heteroarotinoid, that exhibits cytotoxicity in cancer cells with IC₅₀ of 0.37–4.6 μM. SHetA2 regulates cancer cells differentiation, induces apoptosis through the intrinsic mitochondrial pathway, and arrest cell cycle at G2 phase. SHetA2 exhibits good pharmacokinetic characteristics and antitumor efficacy in mice. SHetA2 is orally active.

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Pureté: 99.70%
CAS No.: 361483-66-1
Formule: C₂₀H₂₃N₃O₂S₂
Masse moléculaire:401.55

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SHetA2 Chemical Structure

CAS No.: 361483-66-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Caspase :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	2.98 μM Compound: 5, SHetA2	Growth inhibition of human A2780 cells after 72 hrs by MTS dye based cell titer-96 non-rad cell proliferation assay Growth inhibition of human A2780 cells after 72 hrs by MTS dye based cell titer-96 non-rad cell proliferation assay	[PMID: 25880346]
A2780	IC₅₀	3.17 μM Compound: 1; SHetA2, NSC-721689	Antiproliferative activity against human A2780 cells assessed as reduction in cell growth after 72 hrs by CellTiter 96 Non-Rad cell proliferation assay kit method Antiproliferative activity against human A2780 cells assessed as reduction in cell growth after 72 hrs by CellTiter 96 Non-Rad cell proliferation assay kit method	[PMID: 30878829]
A2780	IC₅₀	3.17 μM Compound: NSC 721689, SHetA2; 1	Growth inhibition of human A2780 cells after 72 hrs by CellTiter-96 assay Growth inhibition of human A2780 cells after 72 hrs by CellTiter-96 assay	[PMID: 30245396]
A2780	IC₅₀	3.17 μM Compound: SHetA2; NSC 721689	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by CellTiter 96 non-radioactive cell proliferation assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by CellTiter 96 non-radioactive cell proliferation assay	[PMID: 31831296]
DU-145	GI₅₀	3.47 μM Compound: SHetA2	Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
DU-145	GI₅₀	4.9 μM Compound: SHetA2	Growth inhibition of human DU145 cells Growth inhibition of human DU145 cells	[PMID: 25701251]
LNCaP	GI₅₀	2.25 μM Compound: SHetA2	Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
MCF7	GI₅₀	4.13 μM Compound: SHetA2	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
MCF7	GI₅₀	4.5 μM Compound: SHetA2	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 25701251]
MDA-MB-453	GI₅₀	3.27 μM Compound: SHetA2	Cytotoxicity against human MDA-MB-453 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-453 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
MDA-MB-453	GI₅₀	5 μM Compound: SHetA2	Growth inhibition of human MDA-MB-453 cells Growth inhibition of human MDA-MB-453 cells	[PMID: 25701251]
PC-3	GI₅₀	4.8 μM Compound: SHetA2	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
PC-3	GI₅₀	5 μM Compound: SHetA2	Growth inhibition of human PC3 cells Growth inhibition of human PC3 cells	[PMID: 25701251]
T47D	GI₅₀	3.99 μM Compound: SHetA2	Cytotoxicity against human T47D cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human T47D cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 25701251]
T47D	GI₅₀	4.8 μM Compound: SHetA2	Growth inhibition of human T47D cells Growth inhibition of human T47D cells	[PMID: 25701251]

Chemical Information

CAS No. 361483-66-1
Appearance Solid
Masse moléculaire 401.55
Formule C₂₀H₂₃N₃O₂S₂
Color White to yellow
SMILES

S=C(NC1=CC=C([N+]([O-])=O)C=C1)NC2=CC3=C(SC(C)(CC3(C)C)C)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang Y, et al., High performance liquid chromatographic analysis and preclinical pharmacokinetics of the heteroarotinoid antitumor agent, SHetA2. Cancer Chemother Pharmacol. 2006 Nov;58(5):561-9. [Content Brief]

[2]. Benbrook DM, et al., Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists. Invest New Drugs. 2005 Oct;23(5):417-28. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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SHetA2

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform Caspase

Activité biologique

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Help & FAQs

SHetA2 Related Classifications

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