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Cat. No.: HY-135487

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Sibenadet

Name: Sibenadet
Brand: MedChemExpress
SKU: HY-135487
Availability: PreOrder

(Synonyms: AR-C68397AA free base; AR-C68397XX)

Sibenadet (AR-C68397AA free base) is a dual dopamine D₂/β₂-adrenoceptor agonist with selective β₂-adrenoceptor agonism. Sibenadet inhibits capsaicin-induced plasma protein extravasation in rat trachea. Sibenadet suppresses edema from sensory nerve fiber activation by activating β₂-adrenoceptor. Sibenadet is promising for research of chronic obstructive pulmonary disease (COPD).

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CAS No.: 154189-40-9
Formule: C₂₂H₂₈N₂O₅S₂
Masse moléculaire:464.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Sibenadet Chemical Structure

CAS No.: 154189-40-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- IC₅₀ & Target
- Cellular Effect
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Activité biologique

Description

IC₅₀ & Target

D₂ Receptor

β2 adrenoceptor

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	4.5 nM Compound: sibenadet	Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase in GTPgamma35S binding by scintillation proximity assay Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase in GTPgamma35S binding by scintillation proximity assay	[PMID: 22932315]

Chemical Information

CAS No. 154189-40-9
Masse moléculaire 464.60
Formule C₂₂H₂₈N₂O₅S₂
SMILES

O=C1SC2=C(CCNCCS(=O)(CCCOCCC3=CC=CC=C3)=O)C=CC(O)=C2N1
Synonyms

AR-C68397AA free base; AR-C68397XX
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Fozard JR, et al. Inhibition by viozan of extravasation induced in rat trachea by capsaicin is mediated exclusively by beta 2-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):570-2. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Sibenadet

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