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Cat. No.: HY-168536

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SJ46411

SJ46411 is a potent ligand for KLHDC2, with a K_d of ~260 nM measured by isothermal titration calorimetry (SPR K_d = 0.5 μM, TR-FRET IC₅₀ = 3.9 μM, ΔTm = 6.0 °C).

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CAS No.: 3086104-39-1
Formule: C₁₇H₁₄N₂O₃S
Masse moléculaire:326.37

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SJ46411 Chemical Structure

CAS No.: 3086104-39-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Description

SJ46411 is a potent ligand for KLHDC2, with a K_d of ~260 nM measured by isothermal titration calorimetry (SPR K_d = 0.5 μM, TR-FRET IC₅₀ = 3.9 μM, ΔTm = 6.0 °C)^[1].

IC₅₀ & Target

KLHDC2

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase :

Chemical Information

CAS No. 3086104-39-1
Masse moléculaire 326.37
Formule C₁₇H₁₄N₂O₃S
SMILES

O=C(CNC(CC1=CSC(C2=CC=C3C=CC=CC3=C2)=N1)=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
Pureté et documentation
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SJ46411

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SJ46411 Related Classifications

HY-168536 Related Classifications