SMK-17
SMK-17 is a selective, non-ATP-competitive MEK1/MEK2 inhibitor with IC50s of 62 nM and 56 nM, respectively. SMK-17 binds to the allosteric pocket of MEK1/2. SMK-17 induces apoptosis in tumor cell lines harboring β-catenin mutations.
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- CAS No.: 765958-29-0
- Formule: C20H24ClF2IN4O2S
- Masse moléculaire:584.85
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Chemical Information
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CAS No. 765958-29-0
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Masse moléculaire 584.85
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Formule C20H24ClF2IN4O2S
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SMILES
O=S(NC1=CC=C(C(F)=C1NC2=CC=C(C=C2Cl)I)F)(N3CCC(CC3)NC(C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)