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Cat. No.: HY-117248

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SR-3737

SR-3737 is a JNK3 and p38 inhibitor (IC₅₀: 12 and 3 nM).

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CAS No.: 1164153-37-0
Formule: C₂₉H₂₅FN₄O₄
Masse moléculaire:512.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

SR-3737 Chemical Structure

CAS No.: 1164153-37-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

SR-3737 is a JNK3 and p38 inhibitor (IC₅₀: 12 and 3 nM)^[1].

Voir tous les produits spécifiques à Isoform JNK :

Voir tous les produits spécifiques à Isoform p38 MAPK :

Chemical Information

CAS No. 1164153-37-0
Masse moléculaire 512.53
Formule C₂₉H₂₅FN₄O₄
SMILES

O=C(NC1=CC(OC)=C(OC)C(OC)=C1)C2=CC=CC(N3N=CC4=C3C=CC(NC5=CC=CC=C5F)=C4)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kamenecka T, et al. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284(19):12853-61. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Protocole
Pureté et documentation
Références

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SR-3737

Voir tous les produits spécifiques à Isoform JNK

Voir tous les produits spécifiques à Isoform p38 MAPK