TRPC5-IN-4
TRPC5-IN-4 is potent and safe TRPC inhibitor with IC50 value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD).
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- CAS No.: 2762315-39-7
- Formule: C18H11ClF4N4O3
- Masse moléculaire:442.75
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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TRPC5 14.07 nM (IC50) |
TRPC4 65 nM (IC50) |
TRPC5-IN-4 (compound 16 g) (0.003-3 μM; 0-1000 seconds) significantly changes intracellular Ca2+ concentration in TRPC4- and TRPC5-HEK293 cells in a dose-dependent manner, and shows very weak inhibitory activity on the TRPC3 channel, no inhibitory effect on TRPC6 and TRPC7 channels[1].
TRPC5-IN-4 (1 and 10 μM; 24 hours) does not reduce the liver and kidney cells viability[1].
TRPC5-IN-4 (0.1, 0.3, 1, 3 μM; 30 minutes) concentration-dependently reduces the PS-induced podocyte rearrangement in MPC5 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary cultured hepatocytes and MPC5 cells[1]
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Concentration:1 and 10 μM
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Incubation Time:24 hours
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Result:Did not reduce the cell viability, suggesting that TRPC5-IN-4 was unlikely to damage the cellular component of liver and kidney.
Chemical Information
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CAS No. 2762315-39-7
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Masse moléculaire 442.75
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Formule C18H11ClF4N4O3
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SMILES
O=C1NC(C(N2CCC3=C(N=CN=C3OC4=C(C=C(C=C4)F)C(F)(F)F)C2)=C1Cl)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRPC5-IN-4 Related Classifications
HY-144429 Related Classifications
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