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Cat. No.: HY-160414

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TRX-COBI

(Synonyms: (R,R)-TRX-COBI; TRX-cobimetinib)

TRX-COBI ((R,R)-TRX-COBI; Trx-cobimetinib) is a MEK inhibitor targeting TRX fragments based on Fe²⁺. TRX-COBI has antitumor activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₃₈H₄₃F₃IN₃O₇
Masse moléculaire:837.66

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TRX-COBI Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

TRX-COBI ((R,R)-TRX-COBI; Trx-cobimetinib) is a MEK inhibitor targeting TRX fragments based on Fe²⁺. TRX-COBI has antitumor activity^[1].

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Chemical Information

Masse moléculaire 837.66
Formule C₃₈H₄₃F₃IN₃O₇
SMILES

FC(C=C(C=C1)I)=C1NC(C(F)=C(C=C2)F)=C2C(N3CC([C@H]4N(C(O[C@H]5C[C@]6(OOC7([C@@H](C8)C[C@H]9C[C@@H]8C[C@@H]7C9)O6)CCC5)=O)CCCC4)(O)C3)=O
Synonyms

(R,R)-TRX-COBI; TRX-cobimetinib
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jiang H, et al. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. J Exp Med. 2022 Apr 4;219(4):e20210739. [Content Brief]

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Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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TRX-COBI

Voir tous les produits spécifiques à Isoform MEK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

TRX-COBI Related Classifications

HY-160414 Related Classifications