country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-158046

Copy Link Print Information

UNC8899

UNC8899 is a STING PROTAC degrader with a DC₅₀ of 1.097 μM. UNC8899 recruits the VHL E3 ligase to mediate the ubiquitination of phosphorylated STING and subsequent proteasomal degradation. UNC8899 can be used in studies of renal cell carcinoma.
(Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3094059-37-4
Formule: C₇₁H₉₁N₁₇O₁₃S
Masse moléculaire:1422.65

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

UNC8899 Chemical Structure

CAS No.: 3094059-37-4

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

UNC8899 is a STING PROTAC degrader with a DC₅₀ of 1.097 μM. UNC8899 recruits the VHL E3 ligase to mediate the ubiquitination of phosphorylated STING and subsequent proteasomal degradation. UNC8899 can be used in studies of renal cell carcinoma^[1]. (Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

IC₅₀ & Target

^[1]

VHL

Voir tous les produits spécifiques à Isoform PROTACs :

In Vitro

UNC8899 (0-31.6 μM；24 h) degrades STING in Caki-1 cells, with a DC50 of 1.097 μM and a Dmax of 99.94%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Caki-1
Concentration:

0.01, 0.0316, 0.1, 0.316, 1, 3.16, 10, 31.6 μM
Incubation Time:

24 h
Result:

Degraded STING in Caki-1 cells, with a DC₅₀ of 1.097 μM and a D_max of 99.94%.

Chemical Information

CAS No. 3094059-37-4
Masse moléculaire 1422.65
Formule C₇₁H₉₁N₁₇O₁₃S
SMILES

O=C(NCCOCCOCCC(N[C@@H](C(N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](C1)O)=O)C(C)(C)C)=O)C4=CC5=C(C(OC)=C4)N(C/C=C/CN6C(NC(C7=CC(C)=NN7CC)=O)=NC8=C6C(OCCCN9CCOCC9)=CC(C(N)=O)=C8)C(NC(C%10=CC(C)=NN%10CC)=O)=N5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhu Z, et al. Development of VHL-recruiting STING PROTACs that suppress innate immunity. Cellular and molecular life sciences : CMLS. 2023 May 14;80(6):149. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

UNC8899

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

UNC8899 Related Classifications

HY-158046 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target