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Cat. No.: HY-150802

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VH101

VH101 is a VHL E3 ligase-recruiting ligand that can be used to generate PROTACs, such as XL01126 (HY-148030).

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CAS No.: 2135318-53-3
Formule: C₂₆H₃₃FN₄O₄S
Masse moléculaire:516.63

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VH101 Chemical Structure

CAS No.: 2135318-53-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

VH101 is a VHL E3 ligase-recruiting ligand that can be used to generate PROTACs, such as XL01126 (HY-148030)^[1].

IC₅₀ & Target^[1]

VHL

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase :

In Vitro

VH101 (100 μM; 4.5 h) pretreatment of LRRK2^G2019S MEFs blocks XL01126-induced LRRK2 degradation, confirming VHL-dependent activity of the PROTAC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2135318-53-3
Masse moléculaire 516.63
Formule C₂₆H₃₃FN₄O₄S
SMILES

O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Liu X, et al. Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. Journal of the American Chemical Society. 2022 Sep 21;144(37):16930-16952. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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VH101

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VH101 Related Classifications

HY-150802 Related Classifications