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Cat. No.: HY-119612

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XCT0135908

(Synonyms: XCT)

XCT0135908 (XCT) is a selective Nurr1-RXRα activator with an EC₅₀ value of 0.3 μM in human dopaminergic SH-SY5Y cells. XCT0135908 protects dopaminergic cells against the Parkinson’s disease-related toxin MPP⁺. XCT0135908 can be used for the research of Parkinson’s disease.

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CAS No.: 300837-31-4
Formule: C₂₁H₁₉N₃O₂
Masse moléculaire:345.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

XCT0135908 Chemical Structure

CAS No.: 300837-31-4

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

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In Vitro

XCT0135908 (Compound 7a) (0.5-12.5 μM; overnight) activates the Nurr1-RXRα heterodimer in human dopaminergic SH-SY5Y cells with an EC₅₀ of 0.3 μM^[1].
XCT0135908 (0.5-12.5 μM; 12 h) selectively activates Nurr1-RXRα and Nur77-RXRα heterodimers (but not other RXRα heterodimers or homodimers) in human dopaminergic SH-SY5Y cells, with greater activation of Nur77GAL4-RXRαVP16 than Nurr1GAL4-RXRαVP16^[1].
XCT0135908 (12.5-50 μM) protects mouse Neuro-2a neuroblast cells from MPP⁺-induced toxicity at concentrations of 12.5 μM and 50 μM, with no observed toxicity at 50 μM^[1].
XCT0135908 (0.5-12.5 μM; 24 h) induces a moderate concentration-dependent increase in SREBP-1c expression in human HepG2 hepatic cells, with a maximal ~5-fold increase at 12.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

human HepG2 hepatic cells
Concentration:

0.5 μM; 12.5 μM
Incubation Time:

24 h
Result:

Triggered a concentration-dependent increase in SREBP-1c expression.
Induced a maximal increase of ~5-fold over controls.

Chemical Information

CAS No. 300837-31-4
Masse moléculaire 345.40
Formule C₂₁H₁₉N₃O₂
SMILES

O=C(O)C1=CC=C(C=C1)NC2=NC(=NC(=C2CC=C)C)C=3C=CC=CC3
Synonyms

XCT
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Asvos X, et al. BRF110, an Orally Active Nurr1-RXRα-Selective Rexinoid, Enhances BDNF Expression without Elevating Triglycerides. J Med Chem. 2025;68(4):4763-4786. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- In Vitro
Chemical Information
Pureté et documentation
Références

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XCT0135908

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