XF067-68
Based on 1 Customer Validation
XF067-68 (example 132) is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5). XF067-68 can be usde for the study of WDR5-mediated diseases.
(Pink: WDR5 ligand (HY-141799); Blue: VHL ligand (HY-173627); Black: linker (HY-Y0966)).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.56%
- CAS No.: 2407452-79-1
- Formule: C52H59F4N9O7S
- Masse moléculaire:1030.14
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Voir tous les produits spécifiques à Isoform PROTACs
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Activité biologique
WDR5[1]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2407452-79-1
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Appearance Solid
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Masse moléculaire 1030.14
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Formule C52H59F4N9O7S
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Color White to off-white
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SMILES
O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@H](N([C@H](C3)C)C)C)C=CC(C4=CC(C(NCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=O)=CC=C4F)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : ≥ 100 mg/mL (97.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9707 mL | 4.8537 mL | 9.7074 mL | 24.2685 mL |
| 5 mM | 0.1941 mL | 0.9707 mL | 1.9415 mL | 4.8537 mL | |
| 10 mM | 0.0971 mL | 0.4854 mL | 0.9707 mL | 2.4269 mL | |
| 15 mM | 0.0647 mL | 0.3236 mL | 0.6472 mL | 1.6179 mL | |
| 20 mM | 0.0485 mL | 0.2427 mL | 0.4854 mL | 1.2134 mL | |
| 25 mM | 0.0388 mL | 0.1941 mL | 0.3883 mL | 0.9707 mL | |
| 30 mM | 0.0324 mL | 0.1618 mL | 0.3236 mL | 0.8090 mL | |
| 40 mM | 0.0243 mL | 0.1213 mL | 0.2427 mL | 0.6067 mL | |
| 50 mM | 0.0194 mL | 0.0971 mL | 0.1941 mL | 0.4854 mL | |
| 60 mM | 0.0162 mL | 0.0809 mL | 0.1618 mL | 0.4045 mL | |
| 80 mM | 0.0121 mL | 0.0607 mL | 0.1213 mL | 0.3034 mL |
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