Chiglitazar sodium
Based on 1 publication(s) in Google Scholar
Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively.
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- Pureté : 98.33%
- CAS No.: 2390374-10-2
- Formule: C36H28FN2NaO4
- Masse moléculaire:594.61
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Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Chiglitazar sodium
More
Activité biologique
Description
IC50 & Target
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PPARα 1.8 μM (EC50) |
PPAR-γ 0.08 μM (EC50) |
PPAR-δ 1.7 μM (EC50) |
In Vitro
Comparative dose-response study of Chiglitazar is performed with rosiglitazone and pioglitazone for PPARγ, and WY14643 for PPARα. Chiglitazar shows significant activation of both the isoforms. Chiglitazar shows weaker PPARγ activating activity than rosiglitazone, but stronger than pioglitazone. In terms of PPARα activation, Chiglitazar shows more potent activity than rosiglitazone, pioglitazone, or WY14643 which is a selective PPARα agonist[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2390374-10-2
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Appearance Solid
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Masse moléculaire 594.61
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Formule C36H28FN2NaO4
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=C(C=C1)F)C(C=CC=C2)=C2N[C@H](C(O[Na])=O)CC(C=C3)=CC=C3OCCN4C5=CC=CC=C5C6=CC=CC=C64
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Synonyms
Carfloglitazar sodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Diabetes Obes Metab
Dapagliflozin and chiglitazar combination enhanced myocardial energy metabolism in high-fat diet-fed mice. [Abstract]2025 Dec 17. PMID: 41403279
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (168.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Li PP, et al. The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Br J Pharmacol. 2006 Jul;148(5):610-8. [Content Brief]
[2]. He BK, et al. In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist. PPAR Res. 2012;2012:546548. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6818 mL | 8.4089 mL | 16.8177 mL | 42.0444 mL |
| 5 mM | 0.3364 mL | 1.6818 mL | 3.3635 mL | 8.4089 mL | |
| 10 mM | 0.1682 mL | 0.8409 mL | 1.6818 mL | 4.2044 mL | |
| 15 mM | 0.1121 mL | 0.5606 mL | 1.1212 mL | 2.8030 mL | |
| 20 mM | 0.0841 mL | 0.4204 mL | 0.8409 mL | 2.1022 mL | |
| 25 mM | 0.0673 mL | 0.3364 mL | 0.6727 mL | 1.6818 mL | |
| 30 mM | 0.0561 mL | 0.2803 mL | 0.5606 mL | 1.4015 mL | |
| 40 mM | 0.0420 mL | 0.2102 mL | 0.4204 mL | 1.0511 mL | |
| 50 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8409 mL | |
| 60 mM | 0.0280 mL | 0.1401 mL | 0.2803 mL | 0.7007 mL | |
| 80 mM | 0.0210 mL | 0.1051 mL | 0.2102 mL | 0.5256 mL | |
| 100 mM | 0.0168 mL | 0.0841 mL | 0.1682 mL | 0.4204 mL |
Chiglitazar sodium Related Classifications
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