2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Chiglitazar sodium

Chiglitazar sodium  (Synonyms: Carfloglitazar sodium)

Cat. No.: HY-106266B
Handling Instructions Technical Support

Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively.

For research use only. We do not sell to patients.

Chiglitazar sodium

Chiglitazar sodium Chemical Structure

CAS No. : 2390374-10-2

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Chiglitazar sodium:

Chiglitazar sodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Chiglitazar sodium

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively.

IC50 & Target

PPARα

1.8 μM (EC50)

PPAR-γ

0.08 μM (EC50)

PPAR-δ

1.7 μM (EC50)

In Vitro

Comparative dose-response study of Chiglitazar is performed with rosiglitazone and pioglitazone for PPARγ, and WY14643 for PPARα. Chiglitazar shows significant activation of both the isoforms. Chiglitazar shows weaker PPARγ activating activity than rosiglitazone, but stronger than pioglitazone. In terms of PPARα activation, Chiglitazar shows more potent activity than rosiglitazone, pioglitazone, or WY14643 which is a selective PPARα agonist[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chiglitazar sodium Related Antibodies
In Vivo

After insulin injection, plasma glucose levels in the MSG rats treated with Chiglitazar or rosiglitazone are significantly reduced compared with the control group treated with vehicle at all time points. Fasting PI levels are lower in animals treated with Chiglitazar and rosiglitazone than control. The ISIs of MSG obese rats treated with chiglitazar and rosiglitazone are significantly higher than control. Furthermore, Chiglitazar ameliorates the HOMA indices. For IPGTT, at the 30?min after glucose loading, the glucose values in the 5 and 10?mg?/kg Chiglitazar and rosiglitazone-treatment groups are significantly lower than those in the vehicle treatment group. The integrated for the glucose response during the IPGTT in the treatment groups are significantly less than those in the control groups[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

594.61

Formula

C36H28FN2NaO4
CAS No.
SMILES

O=C(C1=CC=C(C=C1)F)C(C=CC=C2)=C2N[C@H](C(O[Na])=O)CC(C=C3)=CC=C3OCCN4C5=CC=CC=C5C6=CC=CC=C64
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (168.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6818 mL 8.4089 mL 16.8177 mL
5 mM 0.3364 mL 1.6818 mL 3.3635 mL
View the Complete Stock Solution Preparation Table

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6818 mL 8.4089 mL 16.8177 mL 42.0444 mL
5 mM 0.3364 mL 1.6818 mL 3.3635 mL 8.4089 mL
10 mM 0.1682 mL 0.8409 mL 1.6818 mL 4.2044 mL
15 mM 0.1121 mL 0.5606 mL 1.1212 mL 2.8030 mL
20 mM 0.0841 mL 0.4204 mL 0.8409 mL 2.1022 mL
25 mM 0.0673 mL 0.3364 mL 0.6727 mL 1.6818 mL
30 mM 0.0561 mL 0.2803 mL 0.5606 mL 1.4015 mL
40 mM 0.0420 mL 0.2102 mL 0.4204 mL 1.0511 mL
50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.8409 mL
60 mM 0.0280 mL 0.1401 mL 0.2803 mL 0.7007 mL
80 mM 0.0210 mL 0.1051 mL 0.2102 mL 0.5256 mL
100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.4204 mL
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Chiglitazar sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chiglitazar2390374-10-2CarfloglitazarPPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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