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Cat. No.: HY-163509

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COX-2-IN-43

COX-2-IN-43 (Compound MYM4) is a COX-2 inhibitor (IC₅₀: 0.983 and 0.247 μM for COX-1 and COX-2 respectively). COX-2-IN-43 inhibits cancer cell proliferation and colonization, induces apoptosis.

For research use only. We do not sell to patients.

CAS No.: 1023524-40-4
Formula: C₁₈H₁₁Cl₂F₃N₂O₃
Molecular Weight:431.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

COX-2-IN-43 Chemical Structure

CAS No.: 1023524-40-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

COX-1

0.983 μM (IC₅₀)

COX-2

0.247 μM (IC₅₀)

All COX Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	10.22 μM Compound: MYM4	Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
HEK-293T	IC₅₀	216.97 μM Compound: MYM4	Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
HeLa	IC₅₀	1.57 μM Compound: MYM4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
Hep 3B2	IC₅₀	4.84 μM Compound: MYM4	Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
HepG2	IC₅₀	29.174 μM Compound: MYM4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
LX-2	IC₅₀	20.01 μM Compound: MYM4	Antiproliferative activity against human LX2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human LX2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
MCF7	IC₅₀	20.72 μM Compound: MYM4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]

In Vitro

COX-2-IN-43 shows antiproliferative effects against CaCo-2, Hep3B, and HeLa cancer cell lines, with IC₅₀ values of 10.22, 4.84, and 1.57 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1023524-40-4
Molecular Weight 431.19
Formula C₁₈H₁₁Cl₂F₃N₂O₃
SMILES

CC1=C(C(NC2=CC=C(C=C2)OC(F)(F)F)=O)C(C3=C(C=CC=C3Cl)Cl)=NO1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hawash M, et al. Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling. Eur J Med Chem. 2024 Apr 15;271:116397. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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COX-2-IN-43

All COX Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

COX-2-IN-43 Related Classifications

HY-163509 Related Classifications