CRBN ligand-708
Based on 1 Customer Validation
CRBN ligand-708 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-708 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 97.50%
- CAS No.: 2925094-42-2
- Formula: C11H9BrN4O3
- Molecular Weight:325.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2925094-42-2
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Appearance Solid
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Molecular Weight 325.12
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Formula C11H9BrN4O3
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Color White to off-white
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SMILES
O=C1NC(=O)C(N2N=C3C(Br)=CC=CN3C2=O)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (76.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (245 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0758 mL | 15.3789 mL | 30.7579 mL | 76.8947 mL |
| 5 mM | 0.6152 mL | 3.0758 mL | 6.1516 mL | 15.3789 mL | |
| 10 mM | 0.3076 mL | 1.5379 mL | 3.0758 mL | 7.6895 mL | |
| 15 mM | 0.2051 mL | 1.0253 mL | 2.0505 mL | 5.1263 mL | |
| 20 mM | 0.1538 mL | 0.7689 mL | 1.5379 mL | 3.8447 mL | |
| 25 mM | 0.1230 mL | 0.6152 mL | 1.2303 mL | 3.0758 mL | |
| 30 mM | 0.1025 mL | 0.5126 mL | 1.0253 mL | 2.5632 mL | |
| 40 mM | 0.0769 mL | 0.3845 mL | 0.7689 mL | 1.9224 mL | |
| 50 mM | 0.0615 mL | 0.3076 mL | 0.6152 mL | 1.5379 mL | |
| 60 mM | 0.0513 mL | 0.2563 mL | 0.5126 mL | 1.2816 mL |
CRBN ligand-708 Related Classifications
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