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Cat. No.: HY-W551344

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dCTPase-IN-1

dCTPase-IN-1 is a highly selective deoxycytidine triphosphate pyrophosphatase 1 (dCTPase) inhibitor with an IC₅₀ of 20 nM. dCTPase-IN-1 functionally inhibits dCTPase, exhibits a synergistic effect in enhancing cytotoxicity, and has no inherent cytotoxicity. dCTPase-IN-1 can be used for the research of leukemia.

For research use only. We do not sell to patients.

CAS No.: 353287-72-6
Formula: C₁₅H₁₂N₄O₂S₂
Molecular Weight:344.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

dCTPase-IN-1 Chemical Structure

CAS No.: 353287-72-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Help & FAQs
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Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

dCTPase-IN-1 (compound 18) (1.0-5.0 μM; 72 h) acts synergistically with 5-Azacytidine (HY-10586) to reduce the viability of human leukemia HL60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HL60 human leukemia cells
Concentration:

1.0, 2.5, 5.0 μM (in combination with 2.5 μM 5-Azacytidine)
Incubation Time:

72 h
Result:

Synergistically increased the cytotoxicity of 5-Azacytidine, reducing HL60 cell viability without exhibiting cytotoxicity when used alone.

Chemical Information

CAS No. 353287-72-6
Molecular Weight 344.41
Formula C₁₅H₁₂N₄O₂S₂
SMILES

N=1N=C(C=2SC=CC2)N3N=C(SC13)C=4C=CC(OC)=C(OC)C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Llona-Minguez S, et al. Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. J Med Chem. 2017;60(5):2148-2154. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
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dCTPase-IN-1

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

dCTPase-IN-1 Related Classifications

HY-W551344 Related Classifications