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Art. -Nr.: HY-162859

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AB25583

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC₅₀ value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research.

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Reinheit: 99.87%
CAS. Nr.: 2565637-94-5
Formel: C₂₂H₁₇ClN₄O₃S
Molecular Weight:452.91

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

AB25583 Chemical Structure

CAS. Nr.: 2565637-94-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Helicase

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

AB25583 inhibits ATPase activity of Polθ-hel, inhibits microhomology-mediated end joining (MMEJ) expression, hinders the DNA repair process, thereby leading to DNA damage accumulation, especially in cancer cells with BRCA1/2 deficiency^[1].
AB25583 (0-10 μM, 24 h) causes the phosphorylation of γH2AX in MDA-MB-436 cell (BRCA1 KO mutant), inhibits the cell survival of MDA-MB-436, reduces the colony density^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

MDA-MB-436
Concentration:

0-10 μM
Incubation Time:

24 h
Result:

Promoted the level of phosphorylated γH2AX.

Chemical Information

CAS. Nr. 2565637-94-5
Appearance Solid
Molecular Weight 452.91
Formel C₂₂H₁₇ClN₄O₃S
Color White to off-white
SMILES

ClC1=CC=C(COC2=NN=C(NC(C3=C(C4=CC=CC=C4OC)C=CN=C3)=O)S2)C=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

bioRxiv

2025 Nov 30.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (275.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2079 mL

11.0397 mL

22.0794 mL

5 mM

0.4416 mL

2.2079 mL

4.4159 mL

10 mM

0.2208 mL

1.1040 mL

2.2079 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ito F, et al. Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun. 2024 Aug 14;15(1):7003. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2079 mL	11.0397 mL	22.0794 mL	55.1986 mL
	5 mM	0.4416 mL	2.2079 mL	4.4159 mL	11.0397 mL
	10 mM	0.2208 mL	1.1040 mL	2.2079 mL	5.5199 mL
	15 mM	0.1472 mL	0.7360 mL	1.4720 mL	3.6799 mL
	20 mM	0.1104 mL	0.5520 mL	1.1040 mL	2.7599 mL
	25 mM	0.0883 mL	0.4416 mL	0.8832 mL	2.2079 mL
	30 mM	0.0736 mL	0.3680 mL	0.7360 mL	1.8400 mL
	40 mM	0.0552 mL	0.2760 mL	0.5520 mL	1.3800 mL
	50 mM	0.0442 mL	0.2208 mL	0.4416 mL	1.1040 mL
	60 mM	0.0368 mL	0.1840 mL	0.3680 mL	0.9200 mL
	80 mM	0.0276 mL	0.1380 mL	0.2760 mL	0.6900 mL
	100 mM	0.0221 mL	0.1104 mL	0.2208 mL	0.5520 mL

Keywords

AB25583

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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AB25583

Cell Cycle/DNA Damage Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Cancer Stem Cells Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) AB25583

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

AB25583

Cell Cycle/DNA Damage Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Cancer Stem Cells Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) AB25583

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

AB25583 Related Classifications

HY-162859 Related Classifications