Art. -Nr.: HY-171178

DK2403

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DK2403 (compound 25) is a MAP2K7 inhibitor (IC₅₀= 0.01 μM). DK2403 can effectively inhibit MAP2K7 without significantly disrupting the larger kinase group and can be used to study childhood T-cell acute lymphoblastic leukemia.

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Reinheit: 98.24%
CAS. Nr.: 2902651-64-1
Formel: C₁₉H₁₇ClN₄O₂
Molecular Weight:368.82

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DK2403 Chemical Structure

CAS. Nr.: 2902651-64-1

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	1.4 μM Compound: 25	Cytotoxicity against human Jurkat cells assessed as cell growth inhibition measured after 18 hrs by Celltiter-Glo luminescence assay Cytotoxicity against human Jurkat cells assessed as cell growth inhibition measured after 18 hrs by Celltiter-Glo luminescence assay	[PMID: 37197477]
Jurkat	IC₅₀	1.6 μM Compound: 25	Cytotoxicity against human Jurkat cells assessed as cell growth inhibition measured after 18 hrs followed by compound washout by Celltiter-Glo luminescence assay Cytotoxicity against human Jurkat cells assessed as cell growth inhibition measured after 18 hrs followed by compound washout by Celltiter-Glo luminescence assay	[PMID: 37197477]
Jurkat	IC₅₀	2 μM Compound: 25	Cytotoxicity against human Jurkat cells assessed as cell growth inhibition measured after 48 hrs by Celltiter-Glo luminescence assay Cytotoxicity against human Jurkat cells assessed as cell growth inhibition measured after 48 hrs by Celltiter-Glo luminescence assay	[PMID: 37197477]
KOPTK1	IC₅₀	1.9 μM Compound: 25	Cytotoxicity against human KOPT-K1 cells assessed as cell growth inhibition measured after 18 hrs followed by compound washout by Celltiter-Glo luminescence assay Cytotoxicity against human KOPT-K1 cells assessed as cell growth inhibition measured after 18 hrs followed by compound washout by Celltiter-Glo luminescence assay	[PMID: 37197477]
KOPTK1	IC₅₀	2.2 μM Compound: 25	Cytotoxicity against human KOPT-K1 cells assessed as cell growth inhibition measured after 18 hrs by Celltiter-Glo luminescence assay Cytotoxicity against human KOPT-K1 cells assessed as cell growth inhibition measured after 18 hrs by Celltiter-Glo luminescence assay	[PMID: 37197477]
KOPTK1	IC₅₀	2.8 μM Compound: 25	Cytotoxicity against human KOPT-K1 cells assessed as cell growth inhibition measured after 48 hrs by Celltiter-Glo luminescence assay Cytotoxicity against human KOPT-K1 cells assessed as cell growth inhibition measured after 48 hrs by Celltiter-Glo luminescence assay	[PMID: 37197477]
RPMI 8402	IC₅₀	2.9 μM Compound: 25	Cytotoxicity against human RPMI 8402 cells assessed as cell growth inhibition measured after 48 hrs by Celltiter-Glo luminescence assay Cytotoxicity against human RPMI 8402 cells assessed as cell growth inhibition measured after 48 hrs by Celltiter-Glo luminescence assay	[PMID: 37197477]

Chemical Information

CAS. Nr. 2902651-64-1
Appearance Solid
Molecular Weight 368.82
Formel C₁₉H₁₇ClN₄O₂
Color White to off-white
SMILES

O=C(CCl)NC1=CC(OC2=NC=NC(NCC3=CC=CC=C3)=C2)=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (338.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7113 mL

13.5567 mL

27.1135 mL

5 mM

0.5423 mL

2.7113 mL

5.4227 mL

10 mM

0.2711 mL

1.3557 mL

2.7113 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 6.25 mg/mL (16.95 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 6.25 mg/mL (16.95 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kim DR, et al. Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett. 2023 Apr 17;14(5):606-613. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7113 mL	13.5567 mL	27.1135 mL	67.7837 mL
	5 mM	0.5423 mL	2.7113 mL	5.4227 mL	13.5567 mL
	10 mM	0.2711 mL	1.3557 mL	2.7113 mL	6.7784 mL
	15 mM	0.1808 mL	0.9038 mL	1.8076 mL	4.5189 mL
	20 mM	0.1356 mL	0.6778 mL	1.3557 mL	3.3892 mL
	25 mM	0.1085 mL	0.5423 mL	1.0845 mL	2.7113 mL
	30 mM	0.0904 mL	0.4519 mL	0.9038 mL	2.2595 mL
	40 mM	0.0678 mL	0.3389 mL	0.6778 mL	1.6946 mL
	50 mM	0.0542 mL	0.2711 mL	0.5423 mL	1.3557 mL
	60 mM	0.0452 mL	0.2259 mL	0.4519 mL	1.1297 mL
	80 mM	0.0339 mL	0.1695 mL	0.3389 mL	0.8473 mL
	100 mM	0.0271 mL	0.1356 mL	0.2711 mL	0.6778 mL

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DK2403

Immunology/Inflammation Compound Library

MAPK Compound Library

Anti-Cancer Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Anti-Lung Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Neurodegenerative Disease-related Compound Library

Angiogenesis-Related Compound Library

Pain-Related Compound Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DK2403

Immunology/Inflammation Compound Library

MAPK Compound Library

Anti-Cancer Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Anti-Lung Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Neurodegenerative Disease-related Compound Library

Angiogenesis-Related Compound Library

Pain-Related Compound Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DK2403 Related Classifications

HY-171178 Related Classifications