BCL2L11 - BCL2 like 11 Gene

Also Known as BAM; BIM; BOD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10018

About BCL2L11

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:111,120,914-111,168,445 (from NCBI)

This gene has 23 transcripts (splice variants), 116 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 7.9), thyroid (RPKM 7.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 Family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with Other members of the Bcl-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte Apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of Apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

BCL2L11 Products (33)

mRNA	Protein	Name
XM_005263556.4	XP_005263613.1	bcl-2-like protein 11 isoform X8
XM_017003101.3	XP_016858590.1	bcl-2-like protein 11 isoform X12
NM_001204109.2	NP_001191038.1	bcl-2-like protein 11 isoform 14
XM_047442101.1	XP_047298057.1	bcl-2-like protein 11 isoform X5
XM_047442102.1	XP_047298058.1	bcl-2-like protein 11 isoform X6
NM_138627.4	NP_619533.1	bcl-2-like protein 11 isoform 8
NM_138626.4	NP_619532.1	bcl-2-like protein 11 isoform 7
NM_138623.4	NP_619529.1	bcl-2-like protein 11 isoform 3
NM_138624.4	NP_619530.1	bcl-2-like protein 11 isoform 4
XM_047442104.1	XP_047298060.1	bcl-2-like protein 11 isoform X11
NM_207003.3	NP_996886.1	bcl-2-like protein 11 isoform 10
NM_138621.5	NP_619527.1	bcl-2-like protein 11 isoform 1
XM_005263555.5	XP_005263612.2	bcl-2-like protein 11 isoform X7
XM_005263557.5	XP_005263614.1	bcl-2-like protein 11 isoform X8
XM_005263553.4	XP_005263610.1	bcl-2-like protein 11 isoform X4
NM_006538.5	NP_006529.1	bcl-2-like protein 11 isoform 6
XM_005263559.4	XP_005263616.2	bcl-2-like protein 11 isoform X10
XR_007068187.1
NM_138625.4	NP_619531.1	bcl-2-like protein 11 isoform 5
NM_001204112.2	NP_001191041.1	bcl-2-like protein 11 isoform 17
XR_007068189.1
XM_011510464.4	XP_011508766.1	bcl-2-like protein 11 isoform X9
NM_207002.3	NP_996885.1	bcl-2-like protein 11 isoform 9
XM_047442099.1	XP_047298055.1	bcl-2-like protein 11 isoform X2
NM_138622.4	NP_619528.1	bcl-2-like protein 11 isoform 2
NM_001204113.1	NP_001191042.1	bcl-2-like protein 11 isoform 18
NM_001204107.1	NP_001191036.1	bcl-2-like protein 11 isoform 12
NM_001204110.2	NP_001191039.1	bcl-2-like protein 11 isoform 15
NM_001204108.1	NP_001191037.1	bcl-2-like protein 11 isoform 13
XM_005263552.5	XP_005263609.1	bcl-2-like protein 11 isoform X3
NM_001204111.2	NP_001191040.1	bcl-2-like protein 11 isoform 16
XM_011510461.4	XP_011508763.2	bcl-2-like protein 11 isoform X1
NM_001204106.2	NP_001191035.1	bcl-2-like protein 11 isoform 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
contributes to microtubule binding	IDA IDA: Inferred from direct assay	21671007	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14596824	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	21671007	GOA
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	11546872	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in positive regulation of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	11997495	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21671007	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	21041309	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	19767770	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IGI IGI: Inferred from genetic interaction	21041309	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	18209102	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	22761832	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of BIM-BCL-2 complex	IDA IDA: Inferred from direct assay	21671007	GOA
part of BIM-BCL-xl complex	IDA IDA: Inferred from direct assay	21671007	GOA
part of Bcl-2 family protein complex	IPI IPI: Inferred from physical interaction	20066663	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21671007	GOA
colocalizes with microtubule	IDA IDA: Inferred from direct assay	21671007	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL2L11 Protein Structure

Bim_N

Bclx_interact

0
100
198 a.a.

Protein Preferred Names	Protein Names
bcl-2-like protein 11	BCL2-like 11 (apoptosis facilitator) bcl-2 interacting mediator of cell death bcl-2 interacting protein Bim bcl-2-related ovarian death agonist

BCL2L11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	BCL2L11	O43521	MCL1	Homo sapiens	Q07820	Anti Bait CoIP	21507240
Intra	BCL2L11	O43521	MCL1	Homo sapiens	Q07820	Anti Bait CoIP	26859456
Intra	BCL2L11	O43521	MCL1	Homo sapiens	Q07820	FPS	16697956
Intra	BCL2L11	O43521	MCL1	Homo sapiens	Q07820	SPR	21199865
Intra	BCL2L11	O43521	MCL1	Homo sapiens	Q07820	Anti Bait CoIP	23245996
Intra	BCL2L11	O43521	MCL1	Homo sapiens	Q07820	Anti Tag CoIP	33961781
Intra	BCL2L11	O43521	BCL2A1	Homo sapiens	Q16548	Validated Y2H	32296183
Intra	BCL2L11	O43521	MAGEA11	Homo sapiens	P43364-2	Validated Y2H	25416956
Intra	BCL2L11	O43521	BCL2L10	Homo sapiens	Q9HD36	SPR	23235460
Intra	BCL2L11	O43521	BCL2L10	Homo sapiens	Q9HD36	Validated Y2H	32296183
Intra	BCL2L11	O43521	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	BCL2L11	O43521	BCL2L1	Homo sapiens	Q07817-1	SPR	21199865
Intra	BCL2L11	O43521	BCL2L1	Homo sapiens	Q07817-1	Anti Bait CoIP	23245996
Intra	BCL2L11	O43521	BCL2L1	Homo sapiens	Q07817-1	SPR	17289999
Intra	BCL2L11	O43521	BCL2L1	Homo sapiens	Q07817-1	Anti Bait CoIP	21671007
Intra	BCL2L11	O43521	P4HB	Homo sapiens	P07237	Y2H Pooling	32814053
Intra	BCL2L11	O43521	P4HB	Homo sapiens	P07237	Validated Y2H	32814053
Intra	BCL2L11	O43521	P4HB	Homo sapiens	P07237	Y2H Array	32814053
Intra	BCL2L11	O43521	BAX	Homo sapiens	Q07812	SPR	23374347
Intra	BCL2L11	O43521	BAX	Homo sapiens	Q07812	SPR	17289999
Intra	BCL2L11	O43521	BAX	Homo sapiens	Q07812	SPR	23235460
Intra	BCL2L11	O43521	BAX	Homo sapiens	Q07812	SPR	21199865
Intra	BCL2L11	O43521	BAX	Homo sapiens	Q07812	NMR	18948948
Intra	BCL2L11	O43521	BAX	Homo sapiens	Q07812	GMS	18948948
Intra	BCL2L11	O43521	PEX19	Homo sapiens	P40855	Validated Y2H	32296183
Intra	BCL2L11	O43521	PEX19	Homo sapiens	P40855	Y2H Array	32296183
Intra	BCL2L11	O43521	PEX19	Homo sapiens	P40855	Y2H Prey Pooling	32296183
Cross	BCL2L11	O43521	Mcl1	Mus musculus	P97287	Anti Bait CoIP	20627101
Cross	BCL2L11	O43521	Mcl1	Mus musculus	P97287	Anti Tag CoIP	20627101
Cross	BCL2L11	O43521	Mcl1	Mus musculus	P97287	SPR	17289999
Cross	BCL2L11	O43521	Mcl1	Mus musculus	P97287	SPR	15694340
Intra	BCL2L11	O43521	BCL2L2	Homo sapiens	Q92843	SPR	15694340
Intra	BCL2L11	O43521	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	BCL2L11	O43521	BCL2L2	Homo sapiens	Q92843	FPS	16697956
Intra	BCL2L11	O43521	BCL2L2	Homo sapiens	Q92843	SPR	21199865
Intra	BCL2L11	O43521	BCL2L2	Homo sapiens	Q92843	SPR	17289999
Cross	BCL2L11	O43521	Bcl2a1	Mus musculus	Q07440	SPR	17289999
Cross	BCL2L11	O43521	Bcl2a1	Mus musculus	Q07440	SPR	15694340
Intra	BCL2L11	O43521	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	BCL2L11	O43521	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	BCL2L11	O43521	BCL2	Homo sapiens	P10415	SPR	17289999
Intra	BCL2L11	O43521	BCL2	Homo sapiens	P10415	Anti Bait CoIP	23845444
Intra	BCL2L11	O43521	BCL2	Homo sapiens	P10415	SPR	21199865
Intra	BCL2L11	O43521	BCL2	Homo sapiens	P10415	Anti Tag CoIP	33961781
Intra	BCL2L11	O43521	BCL2	Homo sapiens	P10415	FPS	16697956
Intra	BCL2L11	O43521	BCL2L1	Homo sapiens	Q07817	Anti Tag CoIP	33961781
Intra	BCL2L11	O43521	BCL2L1	Homo sapiens	Q07817	Validated Y2H	32296183
Intra	BCL2L11	O43521	BCL2L1	Homo sapiens	Q07817	FPS	16697956
Intra	BCL2L11	O43521	BCL2L1	Homo sapiens	Q07817	MAPPIT	32296183
Intra	BCL2L11	O43521	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Cross	BCL2L11	O43521	NS	Influenza A virus	P03495	Y2H	24008843
Cross	BCL2L11	O43521	OPG045	Vaccinia virus	P68451	IF	17074758
Cross	BCL2L11	O43521	OPG045	Vaccinia virus	P68451	ITC	18551131
Cross	BCL2L11	O43521	OPG045	Vaccinia virus	P68451	CoIP	17074758

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCL2L11 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P74385	Bcl-2-like protein 11 Protein, Human (His)	O43521-2/NP_006529.1 (A2-R120)	≥ 90%, as determined by reducing SDS-PAGE.

BCL2L11 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80032	Bim Antibody (YA582)	WB, ICC/IF, IHC-P, IP	Human, Mouse
HY-P86326	Bim Antibody (YA6018)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Interleukin-7 Receptor Alpha Deficiency	Il-7r
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Buruli Ulcer	Buruli Ulcer, Susceptibility To Buruli Ulcer Disease Mycobacterium Ulcerans Mycobacterium Ulcerans, Susceptibility To Bairnsdale Ulcer Daintree Ulcer Mossman Ulcer Searl Ulcer Searle'S Ulcer Bud
Ras-Associated Autoimmune Leukoproliferative Disorder	RALD Autoimmune Lymphoproliferative Syndrome Type 4 Alps4 Autoimmune Lymphoproliferative Syndrome, Type Iv Ras-Associated Autoimmune Leukoproliferative Disease Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic Alps Type 4 Alps Type Iv Autoimmune Lymphoproliferative Syndrome Type Iv Autoimmune Lymphoproliferative Syndrome 4
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Mature B-Cell Neoplasm	Mature B-Cell Lymphocytic Neoplasm Neoplasm Of Mature B-Cells Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Myasthenic Syndrome, Congenital, 3a, Slow-Channel	Congenital Myasthenic Syndrome 3a CMS3A Congenital Myasthenic Syndrome 3a, Slow-Channel Myasthenic Syndrome, Congenital, Type 3a, Slow-Channel

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-153953	Bcl-2-IN-11	Inhibitor	/	Unkown
HY-RS01427	BCL2L11 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01428	Bcl2l11 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01429	Bcl2l11 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BCL2L11	MGD	MGI:1197519
Felis catus	BCL2L11	VGNC	VGNC:99046
Macaca mulatta	BCL2L11	VGNC	VGNC:97737
Rattus norvegicus	BCL2L11	RGD	RGD:628774
Canis familiaris	BCL2L11	VGNC	VGNC:54922
Bos taurus	BCL2L11	VGNC	VGNC:50256
Others	BCL2L11	NCBI