ODN 2088
Based on 4 publication(s) in Google Scholar
ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.82%
- CAS. Nr.: 1146541-45-8
- Molecular Weight:4878.00
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ODN 2088
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Biologische Aktivität
ODN 2088 (0.01-10 μM; 48 h) shows no cytotoxic for for human PBMCs[1].
ODN 2088 (0.01-10 μM; 24 h) inhibits the release of IFN-α in CpG-ODN 2216 (3 μM) and TLR7-ligand RNA-ORN 22075 (5 μM) stimulated human PBMCs[1].
ODN 2088 (0.01-10 μM; 48 h) hardly inhibits the IL-6 release stimulated with CpG-ODN 2006 (100 nM) but inhibits the IL-6 release stimulated with Imiquimod (HY-B0180) (5 μg/ml) in human PBMCs[1].
ODN 2088 (0.1-10 μM; 24 h) hardly inhibits IL-6 release by B-cells stimulated with CpG-DNA 2006 (100 nM) but inhibits the IL-6 release by Imiquimod (5 μg/ml) stimulated human B-cells[1].
ODN 2088 presumably impairs TLR9-induced signaling induces by CpG-ODNs by competitive binding to the C-terminal fragment of TLR9[1].
ODN 2088 (0.001-10 μM; 24 h) inhibits the TNF-α secretion in a dose-dependent manner in CpG-ODN 1826 (100 nM) stimulated BMDMs and shows weekly inhibits when stimulated by the TLR7-agonist imiquimod[3].
ODN 2088 (10 μM) stimulates B cells to proliferate[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human PBMCs
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Concentration:0.01, 0.1, 1, 10 μM
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Incubation Time:48 h
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Result:Showed no cytotoxic for for human PBMCs.
Chemical Information
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CAS. Nr. 1146541-45-8
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Appearance Solid
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Molecular Weight 4878.00
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Color White to off-white
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SMILES
[DNA, d(P-thio)(T-C-C-T-G-G-C-G-G-G-G-A-A-G-T)]
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Sequence
DNA, d(P-thio)(T-C-C-T-G-G-C-G-G-G-G-A-A-G-T)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Hepatocyte-derived extracellular vesicles carrying damaged mitochondria drive neutrophil extracellular traps formation and exacerbate acetaminophen-induced liver injury. [Abstract]2026 Jan 15:169:115944. PMID: 41349466 -
Neurochem Res
AQP4-IgG-Induced Astrocyte-Derived Small Extracellular Vesicles Carrying Mitochondrial DNA Regulate the TLR9/MyD88/NF-κB Pathway to Drive Microglial Activation and Neuromyelitis Optica. [Abstract]2026 Feb 11;51(1):73. PMID: 41670763 -
PLoS One
TLR9/MyD88/NF-κB signaling mediates mental stress-induced exacerbation of psoriasis through immune dysregulation in a mouse model. [Abstract]2026 Mar 6;21(3):e0344474. PMID: 41790734 -
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2242 KB)
Verweise
[1]. Römmler F, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS One. 2015 Feb 19;10(2):e0116703. [Content Brief]
[2]. Duramad O, et al. Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. J Immunol. 2005 May 1;174(9):5193-200. [Content Brief]
[3]. Römmler F, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ODN 2088 Related Classifications
HY-150738 Related Classifications
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