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Art. -Nr.: HY-187608

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Ro 44-3888

Ro 44-3888 is an orally active and selective GP IIb-IIIa (fibrinogen receptor, integrin α_IIbβ₃) inhibitor with an IC₅₀ of 1.9 nM against the human target. Ro 44-3888 blocks the binding of fibrinogen to GP IIb-IIIa and inhibits human ADP-induced platelet aggregation. Ro 44‑3888 is formed via the metabolism of the double prodrug Ro 48‑3657 (HY-10309). Ro 44-3888 is used in studies related to arterial thrombosis.

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CAS. Nr.: 144412-18-0
Formel: C₁₈H₂₄N₄O₅
Molecular Weight:376.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ro 44-3888 Chemical Structure

CAS. Nr.: 144412-18-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

GPIIb/IIIa

1.9 nM (IC₅₀)

Alle Integrin Isoform-spezifische Produkte anzeigen :

In Vitro

Ro 44-3888 (compound 13) potently inhibits the binding of fibrinogen to purified human GP IIb-IIIa with an IC₅₀ of 1.9 nM, and effectively suppresses ADP-induced platelet aggregation in human platelet-rich plasma with an IC₅₀ of 38 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Ro 44-3888 (compound 13) is generated via in vivo metabolism after oral administration of Ro 48‑3657 (HY-10309). Its bioavailability is 26 % in rats, 25 % in dogs, and 33 % in rhesus monkeys; the corresponding elimination half-lives are 4.1 h, 11.4 h, and 5.1 h, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 144412-18-0
Molecular Weight 376.41
Formel C₁₈H₂₄N₄O₅
SMILES

O=C(N1CCC(CC1)OCC(O)=O)[C@H](C)NC(C2=CC=C(C=C2)C(N)=N)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Weller T, et al. Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines. Journal of medicinal chemistry. 1996 Aug 02;39(16):3139-47.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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