SA-VA
SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase.
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- CAS. Nr.: 3058085-77-8
- Formel: C50H53ClF3N11O7S
- Molecular Weight:1044.54
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Alle PROTACs Isoform-spezifische Produkte anzeigen
MoreAlle VEGFR Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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VHL |
VEGFR-2 |
EphB4 |
Chemical Information
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CAS. Nr. 3058085-77-8
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Molecular Weight 1044.54
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Formel C50H53ClF3N11O7S
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SMILES
O=C(NCC1=CN(CCCCC(N[C@@H](C(C)(C)C)C(N2[C@H](C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)C[C@@H](O)C2)=O)=O)N=N1)C5=NC=CC(OC6=CC=C(NC(NC7=CC=C(Cl)C(C(F)(F)F)=C7)=O)C=C6)=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SA-VA Related Classifications
HY-155685 Related Classifications
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