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Art. -Nr.: HY-13704S2

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SN-38-¹³C₆

Name: SN-38-13C6
Brand: MedChemExpress
SKU: HY-13704S2
Availability: PreOrder

(Synonyms: 7-Ethyl-10-hydroxycamptothecin-¹³C₆)

SN-38-¹³C₆ (7-Ethyl-10-hydroxycamptothecin-¹³C₆) is the ¹³C-labeled SN-38 (HY-13704). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 718612-55-6
Formel: C₁₆¹³C₆H₂₀N₂O₅
Molecular Weight:398.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SN-38-¹³C₆ Chemical Structure

CAS. Nr.: 718612-55-6

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Biologische Aktivität
- Beschreibung
- In Vitro
- Anwendung
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

Alle Topoisomerase Isoform-spezifische Produkte anzeigen :

Alle ADC Payloads Isoform-spezifische Produkte anzeigen :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 718612-55-6
Unlabeled CAS 86639-52-3
Molecular Weight 398.36
Formel C₁₆¹³C₆H₂₀N₂O₅
SMILES

CCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=N[13C]5=[13CH][13CH]=[13C](O)[13CH]=[13C]51
Synonyms

7-Ethyl-10-hydroxycamptothecin-¹³C₆
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.