L-Cycloserine
Based on 2 publication(s) in Google Scholar
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains.
For research use only. We do not sell to patients.
- Purity: 98.84%
- CAS No.: 339-72-0
- Formula: C3H6N2O2
- Molecular Weight:102.09
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L-Cycloserine
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Splenocyte | IC50 |
3.5 μM
Compound: L-cycloserine
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Inhibition of Concanavalin A-stimulated cell proliferation in mouse splenocytes after 48 hrs by MTT assay
Inhibition of Concanavalin A-stimulated cell proliferation in mouse splenocytes after 48 hrs by MTT assay
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[PMID: 11000020] |
L-Cycloserine inhibits the growth of M. tuberculosis, with an MIC of 0.3 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
L-Cycloserine (30-100 mg/kg, orally or via intraperitoneal injection, twice daily for 5 days) enhances the inhibitory effect on GABA-T activity in mice and boosts its anticonvulsant effects[3].
L-Cycloserine (100-150 mg/kg, subcutaneous or intraperitoneal injection, once daily for 1 week) can reduce the brain content of gangliosides by 28% when injected subcutaneously, with no effect on the content of neurogangliosides; intraperitoneal injection leads to decreased levels of gangliosides and cerebrosides[4].
L-Cycloserine (100 mg/kg, subcutaneous or intraperitoneal injection, single dose) affects the level of inhibition of 3-keto-dihydrosphingosine synthase depending on the method of injection[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Close-crossed epileptic mice (DBA/2J), normal CBNCa mice[2]
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Dosage:25, 50 mg/kg; single dose
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Administration:Intraperitoneal injection (i.p.)
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Result:Protected mice from seizures three hours later, and the effects gradually weakened thereafter, with lower concentrations of glutamate and aspartate in the hypothalamus decreasing and γ-aminobutyric acid increasing.
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Animal Model:DAB/2mice induced by 3-MPA[3]
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Dosage:100 mg/kg; twice a day; 5 days
30 mg/kg; single dose -
Administration:Oral; Intraperitoneal injection (i.p.)
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Result:Enhanced inhibition of GABA-T activity protected mice from 3-mercaptopropionic acid (3-MPA)-induced tonic seizures, and motor performance deficits decreased over time.
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Animal Model:Male Swiss mice[4]
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Dosage:100 mg/kg; single dose
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Administration:Subcutaneous injection (s.c.); Intraperitoneal injection (i.p.)
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Result:Showed that 2 hours after intraperitoneal injection, the synthase activity was found to be inhibited by 80%, and subcutaneous injection of L-cycloserine had no significant inhibitory effect on the synthase within 2-48 hours.
Chemical Information
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CAS No. 339-72-0
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Appearance Solid
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Molecular Weight 102.09
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Formula C3H6N2O2
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Color White to off-white
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SMILES
O=C1NOC[C@@H]1N
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Synonyms
(S)-Cycloserine; (S)-4-Amino-3-isoxazolidone
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Structure Classification
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Initial Source
Erwinia uredovora.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Molecules
Identification of Marrubiin as a Cathepsin C Inhibitor for Treating Rheumatoid Arthritis. [Abstract]2025 Oct 23;30(21):4170. PMID: 41226133 -
Solvent & Solubility
H2O : 100 mg/mL (979.53 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Tathyana Mar Amorim Franco, et al. Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine. ACS Chem Biol. 2017 May 19;12(5):1235-1244. [Content Brief]
[2]. S H Chung, et al. L-cycloserine: a potent anticonvulsant. Epilepsia. 1984 Jun;25(3):353-62. [Content Brief]
[3]. P Polc, et al. L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats. Neuropharmacology. 1986 Apr;25(4):411-8. [Content Brief]
[4]. K S Sundaram, et al. Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine. J Lipid Res. 1985 Apr;26(4):473-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.7953 mL | 48.9764 mL | 97.9528 mL | 244.8820 mL |
| 5 mM | 1.9591 mL | 9.7953 mL | 19.5906 mL | 48.9764 mL | |
| 10 mM | 0.9795 mL | 4.8976 mL | 9.7953 mL | 24.4882 mL | |
| 15 mM | 0.6530 mL | 3.2651 mL | 6.5302 mL | 16.3255 mL | |
| 20 mM | 0.4898 mL | 2.4488 mL | 4.8976 mL | 12.2441 mL | |
| 25 mM | 0.3918 mL | 1.9591 mL | 3.9181 mL | 9.7953 mL | |
| 30 mM | 0.3265 mL | 1.6325 mL | 3.2651 mL | 8.1627 mL | |
| 40 mM | 0.2449 mL | 1.2244 mL | 2.4488 mL | 6.1220 mL | |
| 50 mM | 0.1959 mL | 0.9795 mL | 1.9591 mL | 4.8976 mL | |
| 60 mM | 0.1633 mL | 0.8163 mL | 1.6325 mL | 4.0814 mL | |
| 80 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0610 mL | |
| 100 mM | 0.0980 mL | 0.4898 mL | 0.9795 mL | 2.4488 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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