Cat. No.: HY-113093

Ethyl glucuronide

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Ethyl glucuronide is an endogenous metabolite. Ethyl glucuronide is the metabolite of ethanol. Ethyl glucuronide is a biomarker for ethanol exposure that accumulates in hair and reflects the alcohol intake over a time period. Ethyl glucuronide is the agonist for TLR4.

For research use only. We do not sell to patients.

Purity: 99.22%
CAS No.: 17685-04-0
Formula: C₈H₁₄O₇
Molecular Weight:222.19

Storage:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Ethyl glucuronide Chemical Structure

CAS No.: 17685-04-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All Toll-like Receptor (TLR) Isoforms :

In Vitro

Ethyl glucuronide (0-100 μM, 24 h) blocks the formation of TLR4-MD2 complex, stimulates the expression of TLR4-depenent SEAP protein in HEK-TLR4 cell^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ethyl glucuronide (0.38 µg, intrathecal injection, single dose) reduces the tactile threshold, induces hyperalgesia in Sprague-Dawley rat models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rat models^[2]
Dosage:

0.38 µg
Administration:

intrathecal injection, single dose
Result:

Reduced the tactile threshold.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 17685-04-0
Appearance Solid
Molecular Weight 222.19
Formula C₈H₁₄O₇
Color White to off-white
SMILES

OC([C@@H]1[C@H]([C@@H]([C@@H](O)[C@H](OCC)O1)O)O)=O
Structure Classification
- Saccharides
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (562.57 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.5006 mL

22.5030 mL

45.0059 mL

5 mM

0.9001 mL

4.5006 mL

9.0012 mL

10 mM

0.4501 mL

2.2503 mL

4.5006 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Małkowska A, et al., The influence of caffeine on ethyl glucuronide levels in rat serum and in rat hair. Pharmacol Rep. 2018 Oct;70(5):831-836. [Content Brief]

[2]. Lewis SS, et al., Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun. 2013 May;30:24-32. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	4.5006 mL	22.5030 mL	45.0059 mL	112.5148 mL
	5 mM	0.9001 mL	4.5006 mL	9.0012 mL	22.5030 mL
	10 mM	0.4501 mL	2.2503 mL	4.5006 mL	11.2515 mL
	15 mM	0.3000 mL	1.5002 mL	3.0004 mL	7.5010 mL
	20 mM	0.2250 mL	1.1251 mL	2.2503 mL	5.6257 mL
	25 mM	0.1800 mL	0.9001 mL	1.8002 mL	4.5006 mL
	30 mM	0.1500 mL	0.7501 mL	1.5002 mL	3.7505 mL
	40 mM	0.1125 mL	0.5626 mL	1.1251 mL	2.8129 mL
	50 mM	0.0900 mL	0.4501 mL	0.9001 mL	2.2503 mL
	60 mM	0.0750 mL	0.3750 mL	0.7501 mL	1.8752 mL
	80 mM	0.0563 mL	0.2813 mL	0.5626 mL	1.4064 mL
	100 mM	0.0450 mL	0.2250 mL	0.4501 mL	1.1251 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

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Ethyl glucuronide

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Human Endogenous Metabolite Compound Library

Small Molecule Immuno-Oncology Compound Library

Antioxidant Compound Library

Reprogramming Compound Library

Glycoside Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Food-Sourced Compound Library

Human Metabolite Library

Heterocyclic Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Animal-Sourced Natural Product Library

Immunopotentiator Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Pattern Recognition Receptors Library

Mass Spectrometry Natural Product Library

All Endogenous Metabolite Isoforms

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Ethyl glucuronide Related Classifications

HY-113093 Related Classifications