FAZ-3780
Based on 3 publication(s) in Google Scholar
FAZ-3780 is an inhibitor that binds to the NTF2L domain of G3BP1/2. FAZ-3780 binds to the NTF2L nsP3 of G3BP1 with high affinity, with a Kd of 0.15 μM and a Pep-FRET IC50 of 0.7 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2, and specifically inhibits the co-condensation of G3BP1, caprin 1 and RNA in vitro. FAZ-3780 inhibits stress granule formation and disassembles pre-formed stress granules. FAZ-3780 can be used in studies related to cancer and neurodegenerative diseases.
For research use only. We do not sell to patients.
- Purity : 99.68%
- CAS No.: 3036029-78-1
- Formula: C35H50N4O5
- Molecular Weight:606.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) FAZ-3780
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Biological Activity
Description
In Vitro
FAZ-3780 (G3Ib) (5-50 μM; 2 h) dose-dependently disrupts the interactions between G3BP1 and endogenous caprin 1 as well as USP10 in U2OS cell lysates[1].
FAZ-3780 (25-50 μM; 2 h) disrupts the interaction between the isolated NTF2L domain of G3BP1 and endogenous caprin 1 and USP10 in HEK293T cell lysates[1].
FAZ-3780 (0.001-100 μM; 70 min) potently inhibits the in vitro co-condensation of human G3BP1, caprin 1 and RNA, with an IC50 of 3.450 μM[1].
FAZ-3780 (5-50 μM; 50 min) inhibits sodium arsenite-induced stress granule formation in U2OS/HeLa G3BP1-GFP cells, rapidly disassembles stress granules, and prevents the localization of TDP-43 to stress granules[1].
FAZ-3780 (5-50 μM; 24 h) exhibits sustained and potent inhibitory activity against sodium arsenite-induced stress granule formation in U2OS cells[1].
FAZ-3780 (50 μM; 50 min) inhibits heat shock-induced stress granule formation in U2OS G3BP1-GFP cells and rapidly disassembles pre-formed heat shock-induced stress granules in cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS cells stably expressing G3BP1-GFP
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Concentration:5, 20, 50 μM
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Incubation Time:2 h
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Result:Resulted in a dose-dependent reduction of
the interaction between G3BP1 and both endogenous caprin
1 and endogenous USP10.
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Cell Line:HEK293T cells expressing GFP-NTF2L
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Concentration:25, 50 μM
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Incubation Time:2 h
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Result:Disrupted the interaction of the isolated NTF2L domain of G3BP1 with endogenous caprin 1 and USP10.
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Cell Line:U2OS/Hela G3BP1-GFP cells
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Concentration:5, 20, 50 μM
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Incubation Time:50 min
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Result:Inhibited sodium arsenite-induced G3BP1-GFP signal.
Inhibited heat shock-induced G3BP1-GFP signal.
Rapidly disassembled preformed sodium arsenite-induced G3BP1-GFP signal.
Rapidly disassembled preformed heat shock-induced G3BP1-GFP signal.
Chemical Information
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CAS No. 3036029-78-1
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Appearance Solid
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Molecular Weight 606.80
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Formula C35H50N4O5
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Color White to off-white
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SMILES
O=C(N[C@H](C)C(N1CCC[C@@H]1C2=CC=CC=C2)=O)[C@@H](NC([C@H](C(C)(C)O)NC(CCC(C)(C)C)=O)=O)[C@@H](C)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Cell Biol
2026 Jun;28(6):1204-1218. PMID: 42174134 -
EMBO J
2024 Dec;43(24):6410-6443. PMID: 39533058 -
bioRxiv
Processing bodies promote lysosomal quality control and cell survival during recovery from lysosomal damage. [Abstract]2025 Aug 30:2025.08.27.672666. PMID: 40909692
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (82.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6480 mL | 8.2399 mL | 16.4799 mL | 41.1997 mL |
| 5 mM | 0.3296 mL | 1.6480 mL | 3.2960 mL | 8.2399 mL | |
| 10 mM | 0.1648 mL | 0.8240 mL | 1.6480 mL | 4.1200 mL | |
| 15 mM | 0.1099 mL | 0.5493 mL | 1.0987 mL | 2.7466 mL | |
| 20 mM | 0.0824 mL | 0.4120 mL | 0.8240 mL | 2.0600 mL | |
| 25 mM | 0.0659 mL | 0.3296 mL | 0.6592 mL | 1.6480 mL | |
| 30 mM | 0.0549 mL | 0.2747 mL | 0.5493 mL | 1.3733 mL | |
| 40 mM | 0.0412 mL | 0.2060 mL | 0.4120 mL | 1.0300 mL | |
| 50 mM | 0.0330 mL | 0.1648 mL | 0.3296 mL | 0.8240 mL | |
| 60 mM | 0.0275 mL | 0.1373 mL | 0.2747 mL | 0.6867 mL | |
| 80 mM | 0.0206 mL | 0.1030 mL | 0.2060 mL | 0.5150 mL |
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