Hydroxymethyl dasatinib
Based on 1 Customer Validation
Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC50 of 46.7nM in K562 CML cells.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 910297-58-4
- Formula: C22H26ClN7O3S
- Molecular Weight:504.00
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 910297-58-4
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Appearance Solid
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Molecular Weight 504.00
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Formula C22H26ClN7O3S
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Color White to light yellow
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SMILES
O=C(NC1=C(C=CC=C1Cl)CO)C2=CN=C(S2)NC3=CC(N4CCN(CC4)CCO)=NC(C)=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (248.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (784 KB)
- English - EN (784 KB)
- Français - FR (784 KB)
- Deutsch - DE (784 KB)
- Norwegian - NO (784 KB)
- Español - ES (784 KB)
- Swedish - SV (784 KB)
- Italian - IT (784 KB)
- Portuguese - PT (784 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9841 mL | 9.9206 mL | 19.8413 mL | 49.6032 mL |
| 5 mM | 0.3968 mL | 1.9841 mL | 3.9683 mL | 9.9206 mL | |
| 10 mM | 0.1984 mL | 0.9921 mL | 1.9841 mL | 4.9603 mL | |
| 15 mM | 0.1323 mL | 0.6614 mL | 1.3228 mL | 3.3069 mL | |
| 20 mM | 0.0992 mL | 0.4960 mL | 0.9921 mL | 2.4802 mL | |
| 25 mM | 0.0794 mL | 0.3968 mL | 0.7937 mL | 1.9841 mL | |
| 30 mM | 0.0661 mL | 0.3307 mL | 0.6614 mL | 1.6534 mL | |
| 40 mM | 0.0496 mL | 0.2480 mL | 0.4960 mL | 1.2401 mL | |
| 50 mM | 0.0397 mL | 0.1984 mL | 0.3968 mL | 0.9921 mL | |
| 60 mM | 0.0331 mL | 0.1653 mL | 0.3307 mL | 0.8267 mL | |
| 80 mM | 0.0248 mL | 0.1240 mL | 0.2480 mL | 0.6200 mL | |
| 100 mM | 0.0198 mL | 0.0992 mL | 0.1984 mL | 0.4960 mL |
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