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Cat. No.: HY-117595

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PHM16

PHM16 is an ATP competitive inhibitor of FAK and FGFR2 (IC₅₀: 0.4 μM and 0.37 μM, respectively), with direct potent anti-angiogenic activity.

For research use only. We do not sell to patients.

CAS No.: 1448791-29-4
Formula: C₂₀H₂₂N₆O₄
Molecular Weight:410.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PHM16 Chemical Structure

CAS No.: 1448791-29-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PHM16 is an ATP competitive inhibitor of FAK and FGFR2 (IC₅₀: 0.4 μM and 0.37 μM, respectively), with direct potent anti-angiogenic activity^[1].

IC₅₀ & Target^[1]

FGFR2

0.37 μM (IC₅₀)

FAK

0.4 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	IC₅₀	2.5 μM Compound: 23	Antiangiogenic activity in HUVEC assessed as inhibition of VEGF-stimulated proliferation after 72 hrs by WST-1 assay Antiangiogenic activity in HUVEC assessed as inhibition of VEGF-stimulated proliferation after 72 hrs by WST-1 assay	[PMID: 23845217]

In Vitro

PHM16 inhibits endothelial cell viability, adherence and tube formation along with the added ability to induce endothelial cell apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1448791-29-4
Molecular Weight 410.43
Formula C₂₀H₂₂N₆O₄
SMILES

O=C(C1=C(NC2=NC(NC3=CC(OC)=C(C(OC)=C3)OC)=NC=N2)C=CC=C1)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pascal Dao, et al. Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities. Cancer Lett. 2014 Jun 28;348(1-2):88-99. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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