Cat. No.: HY-N3149

(E)-2-Hydroxycinnamaldehyde

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(E)-2-Hydroxycinnamaldehyde is an aldehyde that can be separated from the stem bark of cinnamon. (E)-2-Hydroxycinnamaldehyde inhibits cell proliferation and induces apoptosis by inhibiting signal transduction of STAT3 and reactive oxygen species production. (E)-2-Hydroxycinnamaldehyde has antitumor activity.

For research use only. We do not sell to patients.

Purity: 99.83%
CAS No.: 60125-23-7
Formula: C₉H₈O₂
Molecular Weight:148.16

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

(E)-2-Hydroxycinnamaldehyde Chemical Structure

CAS No.: 60125-23-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	6.17 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 23855266]
HCT-116	IC₅₀	6.62 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 23855266]
HCT-116	IC₅₀	8.14 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by SRB assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by SRB assay	[PMID: 23855266]
SW-620	GI₅₀	15 μM Compound: 1, HCA	Cytotoxicity against human SW620 cells after 48 hrs by WST1 assay Cytotoxicity against human SW620 cells after 48 hrs by WST1 assay	[PMID: 21183341]

Chemical Information

CAS No. 60125-23-7
Appearance Solid
Molecular Weight 148.16
Formula C₉H₈O₂
Color Yellow to brown
SMILES

O=C/C=C/C1=C(C=CC=C1)O
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 350 mg/mL (2362.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.7495 mL

33.7473 mL

67.4946 mL

5 mM

1.3499 mL

6.7495 mL

13.4989 mL

10 mM

0.6749 mL

3.3747 mL

6.7495 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yoon YJ, et al. 2'-Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation. Cancer Sci. 2019 Jan;110(1):366-378. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.7495 mL	33.7473 mL	67.4946 mL	168.7365 mL
	5 mM	1.3499 mL	6.7495 mL	13.4989 mL	33.7473 mL
	10 mM	0.6749 mL	3.3747 mL	6.7495 mL	16.8736 mL
	15 mM	0.4500 mL	2.2498 mL	4.4996 mL	11.2491 mL
	20 mM	0.3375 mL	1.6874 mL	3.3747 mL	8.4368 mL
	25 mM	0.2700 mL	1.3499 mL	2.6998 mL	6.7495 mL
	30 mM	0.2250 mL	1.1249 mL	2.2498 mL	5.6245 mL
	40 mM	0.1687 mL	0.8437 mL	1.6874 mL	4.2184 mL
	50 mM	0.1350 mL	0.6749 mL	1.3499 mL	3.3747 mL
	60 mM	0.1125 mL	0.5625 mL	1.1249 mL	2.8123 mL
	80 mM	0.0844 mL	0.4218 mL	0.8437 mL	2.1092 mL
	100 mM	0.0675 mL	0.3375 mL	0.6749 mL	1.6874 mL

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(E)-2-Hydroxycinnamaldehyde

Apoptosis Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Medicine Food Homology Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Cancer Stem Cells Compound Library

Cysteine Targeted Covalent Fragment Library

Cell Death Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

All STAT Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

(E)-2-Hydroxycinnamaldehyde Related Classifications

HY-N3149 Related Classifications