ERα antagonist 1
Based on 1 Customer Validation
ERα antagonist 1 (Compound 19d) is a potent, selective, covalent estrogen receptor α (ERα) antagonist. ERα antagonist 1 induces apoptosis and cell cycle G0/G1 phase arrest in MCF-7 cells.
For research use only. We do not sell to patients.
- Purity: 95.92%
- CAS No.: 2762423-09-4
- Formula: C33H32N2O5S
- Molecular Weight:568.68
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERα |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Ishikawa | IC50 |
10.3 μM
Compound: 19d
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Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
|
[PMID: 34509864] |
| MCF7 | IC50 |
1.31 μM
Compound: 19d
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Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
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[PMID: 34509864] |
| MDA-MB-231 | IC50 |
>50 μM
Compound: 19d
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Antiproliferative activity against ER-negative human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against ER-negative human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
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[PMID: 34509864] |
Chemical Information
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CAS No. 2762423-09-4
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Appearance Solid
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Molecular Weight 568.68
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Formula C33H32N2O5S
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Color Light yellow to yellow
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SMILES
O=C(C1=C(SC2=CC(O)=CC=C21)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OC5CN(C5)C/C=C/C(N6CCCCC6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERα antagonist 1 Related Classifications
HY-144733 Related Classifications
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