RS14203
RS14203 is an orally active type IV cyclic nucleotide phosphodiesterase (PDE IV) inhibitor which can induce emesis.
For research use only. We do not sell to patients.
- CAS No.: 159925-31-2
- Formula: C21H15N3O2
- Molecular Weight:341.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
PDE4 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.07 nM
Compound: 5
|
Inhibition of recombinant human PDE4A expressed in Sf9 cells
Inhibition of recombinant human PDE4A expressed in Sf9 cells
|
[PMID: 11052785] |
| Sf9 | IC50 |
5 nM
Compound: 11; CHEMBL127944
|
Inhibition of recombinant human PDE4D7 catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
Inhibition of recombinant human PDE4D7 catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
|
[PMID: 26908025] |
| Sf9 | IC50 |
70 pM
Compound: 11; CHEMBL127944
|
Inhibition of recombinant human PDE4B catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
Inhibition of recombinant human PDE4B catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
|
[PMID: 26908025] |
Chemical Information
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CAS No. 159925-31-2
-
Molecular Weight 341.36
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Formula C21H15N3O2
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SMILES
O=[N+]([O-])C1=CC=CC(C2=CC(CC3=CC=NC=C3)=CC4=C2N=CC=C4)=C1
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Synonyms
PMNPQ
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)