DFP00173
Based on 7 publication(s) in Google Scholar
DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ～0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.46%
- No. CAS: 672286-03-2
- Fòrmula: C11H7Cl2N3O3S
- Peso molecular:332.16
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) DFP00173
More- Carbohydr Polym. 2025 Dec 10;376:124810.
- Int J Mol Sci. 2024 Sep 4;25(17):9604. [Abstract]
- Anal Biochem. 2022 Dec 15:659:114934. [Abstract]
- Biochim Biophys Acta Gen Subj. 2023 Jul;1867(7):130371. [Abstract]
- Biochem Biophys Res Commun. 2023 Oct 8:676:158-164. [Abstract]
- arXiv. 2025 Jul 3.
- Preprints. 2025 Jun 4.
Actividad biológica
DFP00173 inhibits the glycerol permeability of human erythrocytes with an IC50 of ~0.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 672286-03-2
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Appearance Solid
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Peso molecular 332.16
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Fòrmula C11H7Cl2N3O3S
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Color Light yellow to yellow
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SMILES
O=C(NC1=CSC([N+]([O-])=O)=C1)NC2=C(Cl)C=CC=C2Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (7)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
Aquaporin-3a Dysfunction Impairs Osmoadaptation in Post-Activated Marine Fish Spermatozoa. [Abstract]2024 Sep 4;25(17):9604. PMID: 39273548 -
Anal Biochem
Application of a HyPer-3 sensor to monitor intracellular H2O2 generation induced by phenolic acids in differentiated Caco-2 cells. [Abstract]2022 Dec 15:659:114934. PMID: 36206845 -
Biochim Biophys Acta Gen Subj
2023 Jul;1867(7):130371. PMID: 37121280 -
Biochem Biophys Res Commun
Aquaporin 3 inhibition suppresses the mitochondrial respiration rate and viability of multiple myeloma cells. [Abstract]2023 Oct 8:676:158-164. PMID: 37517218 -
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Solvente y solubilidad
DMSO : ≥ 100 mg/mL (301.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0106 mL | 15.0530 mL | 30.1060 mL | 75.2649 mL |
| 5 mM | 0.6021 mL | 3.0106 mL | 6.0212 mL | 15.0530 mL | |
| 10 mM | 0.3011 mL | 1.5053 mL | 3.0106 mL | 7.5265 mL | |
| 15 mM | 0.2007 mL | 1.0035 mL | 2.0071 mL | 5.0177 mL | |
| 20 mM | 0.1505 mL | 0.7526 mL | 1.5053 mL | 3.7632 mL | |
| 25 mM | 0.1204 mL | 0.6021 mL | 1.2042 mL | 3.0106 mL | |
| 30 mM | 0.1004 mL | 0.5018 mL | 1.0035 mL | 2.5088 mL | |
| 40 mM | 0.0753 mL | 0.3763 mL | 0.7526 mL | 1.8816 mL | |
| 50 mM | 0.0602 mL | 0.3011 mL | 0.6021 mL | 1.5053 mL | |
| 60 mM | 0.0502 mL | 0.2509 mL | 0.5018 mL | 1.2544 mL | |
| 80 mM | 0.0376 mL | 0.1882 mL | 0.3763 mL | 0.9408 mL | |
| 100 mM | 0.0301 mL | 0.1505 mL | 0.3011 mL | 0.7526 mL |
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