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GRAP2 - GRB2 related adaptor protein 2 Gene

Also Known as P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9402

About GRAP2

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,893,820-39,973,721 (from NCBI)

This gene has 7 transcripts (splice variants), 260 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 6.7), spleen (RPKM 4.1) and 17 other tissues.

Summary

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with Other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GRAP2 Products (5)

mRNA	Protein	Name
NM_001291824.2	NP_001278753.1	GRB2-related adapter protein 2 isoform 1
NM_001291825.1	NP_001278754.1	GRB2-related adapter protein 2 isoform 1
NM_001291826.2	NP_001278755.1	GRB2-related adapter protein 2 isoform 2
NM_001291828.2	NP_001278757.1	GRB2-related adapter protein 2 isoform 3
NM_004810.4	NP_004801.1	GRB2-related adapter protein 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12359715	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21179510	GOA
located in endosome	IDA IDA: Inferred from direct assay	21179510	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21179510	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRAP2 Protein Structure

SH3_1

SH2

SH3_1

0
100
200
300
330 a.a.

Protein Preferred Names	Protein Names
GRB2-related adapter protein 2	GRB-2-like protein

GRAP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	GRAP2	O75791	ZNF250	Homo sapiens	P15622-3	Validated Y2H	32296183
Intra	GRAP2	O75791	ZSCAN21	Homo sapiens	Q9Y5A6	Anti Tag CoIP	33961781
Intra	GRAP2	O75791	ZSCAN21	Homo sapiens	Q9Y5A6	Anti Tag CoIP	28514442
Intra	GRAP2	O75791	ZSCAN21	Homo sapiens	Q9Y5A6	Validated Y2H	32296183
Intra	GRAP2	O75791	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	GRAP2	O75791	PRR35	Homo sapiens	P0CG20	Validated Y2H	32296183
Intra	GRAP2	O75791	ZNF319	Homo sapiens	Q9P2F9	Validated Y2H	32296183
Intra	GRAP2	O75791	KIT	Homo sapiens	P10721	FPS	24728074
Intra	GRAP2	O75791	PRKAA2	Homo sapiens	P54646	Validated Y2H	32296183
Cross	GRAP2	O75791	Kcnma1	Mus musculus	Q08460	Protein Array	17065230
Intra	GRAP2	O75791	MOS	Homo sapiens	P00540	Validated Y2H	32296183
Intra	GRAP2	O75791	RAVER1	Homo sapiens	Q8IY67	Validated Y2H	32296183
Intra	GRAP2	O75791	EGFR	Homo sapiens	P00533	Lumier	24658140
Intra	GRAP2	O75791	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	GRAP2	O75791	EGFR	Homo sapiens	P00533	Ub Reconstruction	31980649
Intra	GRAP2	O75791	GAREM1	Homo sapiens	Q9H706	Validated Y2H	32296183
Intra	GRAP2	O75791	GAREM1	Homo sapiens	Q9H706	Anti Tag CoIP	33961781
Intra	GRAP2	O75791	LCP2	Homo sapiens	Q13094	X-Ray Diffraction	17010654
Intra	GRAP2	O75791	LCP2	Homo sapiens	Q13094	Validated Y2H	32296183
Intra	GRAP2	O75791	LCP2	Homo sapiens	Q13094	Anti Tag CoIP	17235283
Intra	GRAP2	O75791	LCP2	Homo sapiens	Q13094	Lumier	37398436
Intra	GRAP2	O75791	LCP2	Homo sapiens	Q13094	MAPPIT	32296183
Intra	GRAP2	O75791	LCP2	Homo sapiens	Q13094	SPR	17235283
Intra	GRAP2	O75791	LCP2	Homo sapiens	Q13094	Y2H Array	25416956
Intra	GRAP2	O75791	LCP2	Homo sapiens	Q13094	Complementation	32296183
Intra	GRAP2	O75791	LCP2	Homo sapiens	Q13094	BFG-2H	27107012
Intra	GRAP2	O75791	STAMBP	Homo sapiens	O95630	Y2H	16730941
Intra	GRAP2	O75791	STAMBP	Homo sapiens	O95630	Y2H Array	31515488
Intra	GRAP2	O75791	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	33961781
Intra	GRAP2	O75791	STAMBP	Homo sapiens	O95630	Y2H Pooling	16189514
Intra	GRAP2	O75791	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	28514442
Intra	GRAP2	O75791	GAB1	Homo sapiens	Q13480	Pull Down	10913131
Intra	GRAP2	O75791	GAB1	Homo sapiens	Q13480	Anti Tag CoIP	33961781
Intra	GRAP2	O75791	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	GRAP2	O75791	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	GRAP2	O75791	PTPN23	Homo sapiens	Q9H3S7	Anti Tag CoIP	33961781
Intra	GRAP2	O75791	PTPN23	Homo sapiens	Q9H3S7	Far-WB	21179510
Intra	GRAP2	O75791	PTPN23	Homo sapiens	Q9H3S7	IF	21179510
Intra	GRAP2	O75791	PTPN23	Homo sapiens	Q9H3S7	Anti Tag CoIP	28514442
Intra	GRAP2	O75791	LNX1	Homo sapiens	Q8TBB1	BFG-2H	27107012
Intra	GRAP2	O75791	SPRY2	Homo sapiens	O43597	Validated Y2H	25416956
Intra	GRAP2	O75791	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
Intra	GRAP2	O75791	PBLD	Homo sapiens	P30039	Validated Y2H	32296183
Intra	GRAP2	O75791	q7z783_human	Homo sapiens	Q7Z783	Validated Y2H	32296183
Intra	GRAP2	O75791	GAB2	Homo sapiens	Q9UQC2	Anti Tag CoIP	33961781
Intra	GRAP2	O75791	GAB2	Homo sapiens	Q9UQC2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GRAP2 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81333	GRAP2 Antibody (YA1078)	WB	Human
HY-P81333A	GRAP2 Antibody (YA1078)(PBS only)	WB	Human
HY-P85621	GRAP2 Antibody (YA5313)	WB	Human

Related Diseases

Diseases	Alias
Isolated Growth Hormone Deficiency, Type Ib	Isolated Growth Hormone Deficiency Type Ib IGHD1B Ighd Ib Growth Hormone Deficiency, Isolated, Type Ib Congenital Ighd Type Ib Congenital Isolated Gh Deficiency Type Ib Congenital Isolated Growth Hormone Deficiency Type Ib Dwarfism Of Sindh Pituitary Dwarfism I Isolated Growth Hormone Deficiency Type 1b Ighd 1b Growth Hormone Deficiency, Isolated, 1b
Generalized Anxiety Disorder	Anxiety Generalized
Hypochondriasis	Hypochondriacal Disorder Hypochondria Hypochondriacal Neurosis Illness Anxiety Disorder Health Anxiety Disorder Hypochondriacal Reaction
Somatization Disorder	Somatoform Disorders Briquet'S Disorder Polysomatising Disorder Somatisation Disorder Somatoform Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS05776	GRAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GRAP2	VGNC	VGNC:73156
Canis familiaris	GRAP2	VGNC	VGNC:41470
Rattus norvegicus	GRAP2	RGD	RGD:1307605
Bos taurus	GRAP2	VGNC	VGNC:29627
Felis catus	GRAP2	VGNC	VGNC:67455
Mus musculus	GRAP2	MGD	MGI:1333842
Others	GRAP2	NCBI