NR-11c
Based on 1 Customer Validation
NR-11c is a selective and potent p38α PROTAC degrader. NR-11c effectively degrades p38α in a variety of tumor cells. When administered intraperitoneally or intravenously to mice, NR-11c primarily acts in the liver. NR-11c can be used in cancer research. (Pink: p38α inhibitor 5 (HY-159799); Black: linker (HY-159800); Blue: VHL E3 ligase ligand (HY-112078)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.75%
- Fòrmula: C59H71BrF2N10O8S
- Peso molecular:1198.22
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Ver todos los productos específicos de isoformas PROTACs
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Actividad biológica
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p38α |
NR-11c (1-1000 nM; 24 h) effectively degrades p38α in a variety of tumor cell lines, among which in MDA-MB-231 cells, DC50 is 11.55 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS, MG63, SAOS-2, BBL358, MDA-MB-231 and T47D cells
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Concentration:1 μM
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Incubation Time:24 h
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Result:Significantly reduced the level of p38α.
Chemical Information
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Appearance Solid
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Peso molecular 1198.22
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Fòrmula C59H71BrF2N10O8S
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Color White to off-white
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SMILES
O=C([C@H]1N(C([C@@H](NC(CCCCCNC(CCCN2N=NC(CCCNC(C3=CC=C(C)C(N4C(C)=CC(OCC5=CC=C(F)C=C5F)=C(Br)C4=O)=C3)=O)=C2)=O)=O)C(C)(C)C)=O)C[C@@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (83.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8346 mL | 4.1729 mL | 8.3457 mL | 20.8643 mL |
| 5 mM | 0.1669 mL | 0.8346 mL | 1.6691 mL | 4.1729 mL | |
| 10 mM | 0.0835 mL | 0.4173 mL | 0.8346 mL | 2.0864 mL | |
| 15 mM | 0.0556 mL | 0.2782 mL | 0.5564 mL | 1.3910 mL | |
| 20 mM | 0.0417 mL | 0.2086 mL | 0.4173 mL | 1.0432 mL | |
| 25 mM | 0.0334 mL | 0.1669 mL | 0.3338 mL | 0.8346 mL | |
| 30 mM | 0.0278 mL | 0.1391 mL | 0.2782 mL | 0.6955 mL | |
| 40 mM | 0.0209 mL | 0.1043 mL | 0.2086 mL | 0.5216 mL | |
| 50 mM | 0.0167 mL | 0.0835 mL | 0.1669 mL | 0.4173 mL | |
| 60 mM | 0.0139 mL | 0.0695 mL | 0.1391 mL | 0.3477 mL | |
| 80 mM | 0.0104 mL | 0.0522 mL | 0.1043 mL | 0.2608 mL |
NR-11c Related Classifications
HY-159798 Related Classifications
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