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Pumitamig

(Synonyms: PM-8002; BNT-327)
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Based on 1 Customer Validation

Pumitamig (PM-8002, BNT-327) is a bispecific antibody targeting PD-L1 and VEGF-A, with immune activation and anti-angiogenic activities. By binding to PD-L1, Pumitamig restores the function of effector T cells, while neutralizing VEGF-A in the tumor microenvironment to reverse its inhibition on the infiltration and activation of immune cells and normalize tumor blood vessels. Pumitamig can also be combined with various ADCs targeting TROP2, B7H3, HER2, HER3 for the research of advanced/metastatic solid tumors, including non-small cell lung cancer, ovarian cancer, triple-negative breast cancer, cervical cancer, etc. Pumitamig also exhibits potential efficacy in "cold" tumors with low PD-L1 expression that are insensitive to immunotherapy.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 99.6%
  • Peso molecular:172.48 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pumitamig
  • Experimental Validation Results for Pumitamig
  • Experimental Validation Results for Pumitamig
  • Experimental Validation Results for Pumitamig
  • Experimental Validation Results for Pumitamig
  • Pumitamig Chemical Structure
    Pumitamig Chemical Structure
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-kappa-VH

  • 1/16

    Immobilized hu-PD-L1-ECD-His can bind PM-8002. The EC50 for this effect is 116.7 ng/mL.

  • 1/16

    Immobilized rhVEGF can bind PM-8002. The EC50 for this effect is 19.39 ng/mL.

  • 1/16

    Flow Cytometry analysis of Hela cells labelling PD-1 (red) with Pumitamig (anti-PD-1) (HY-P991097). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99991, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Flow Cytometry analysis of K562 cells labelling VEGF (red) with Pumitamig (HY-P991097). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Pumitamig Chemical Structure
    1/16
  • Pumitamig
  • Immobilized hu-PD-L1-ECD-His can bind PM-8002. The EC50 for this effect is 116.7 ng/mL.
  • Immobilized rhVEGF can bind PM-8002. The EC50 for this effect is 19.39 ng/mL.
  • Flow Cytometry analysis of Hela cells labelling PD-1 (red) with Pumitamig (anti-PD-1) (HY-P991097). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99991, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Flow Cytometry analysis of K562 cells labelling VEGF (red) with Pumitamig (HY-P991097). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa-VH