1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. FM-479

FM-479 

Cat. No.: HY-131014
Handling Instructions

FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

For research use only. We do not sell to patients.

FM-479 Chemical Structure

FM-479 Chemical Structure

CAS No. : 2226521-64-6

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Description

FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

IC50 & Target

JAK3

 

In Vitro

FM-479 is the inactive control of FM-381, the concentration used in assays is similar[1].

Molecular Weight

442.51

Formula

C₂₅H₂₆N₆O₂

CAS No.

2226521-64-6

SMILES

O=C(N(C)C)/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FM-479FM479FM 479JAKJanus kinasenegativecontrolJAK3FM-381kinasecovalentreversibleInhibitorinhibitorinhibit

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FM-479
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HY-131014
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