M‑89
Based on 1 Customer Validation
M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to study MLL leukemia. M-89 inhibits the cell growth in leukemia cell lines carrying MLL fusion.
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- Pureté : 99.14%
- CAS No.: 2363165-42-6
- Formule: C37H47N5O4S
- Masse moléculaire:657.87
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
Kd: 1.4 nM (menin)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
10.2 μM
Compound: 42; M-89
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Growth inhibition of human HL60 cells after 4 days by WST-8 assay
Growth inhibition of human HL60 cells after 4 days by WST-8 assay
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[PMID: 31244110] |
| MOLM-13 | IC50 |
0.054 μM
Compound: 42; M-89
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Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
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[PMID: 31244110] |
| MV4-11 | IC50 |
0.025 μM
Compound: 42; M-89
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Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
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[PMID: 31244110] |
In Vitro
M-89 inhibits the cell growth of MV4;11 cell line with an IC50 of 25 nM[1].
M-89 inhibits the cell growth of HL-60 cell line with an IC50 of 10.2 μM[1].
M-89 (3.7-300 nM) stabilized the cellular menin protein in both MV4;11 and MOLM-13 cells dose-dependently[1].
M-89 (0.03-3 μM, 48 h) induces a time- and dose-dependent apoptosis in MV4;11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2363165-42-6
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Appearance Solid
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Masse moléculaire 657.87
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Formule C37H47N5O4S
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Color White to off-white
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SMILES
O=C(NC)O[C@@H]1[C@@H]([C@]2(C3CCN(CC4CN(C5=CC=C(S(=O)(C6=CC=NC=C6)=O)C=C5)C4)CC3)CN(C)CC7=C2C=CC=C7)CCC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
In Vitro:
DMSO : 7.35 mg/mL (11.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5201 mL | 7.6003 mL | 15.2006 mL | 38.0014 mL |
| 5 mM | 0.3040 mL | 1.5201 mL | 3.0401 mL | 7.6003 mL | |
| 10 mM | 0.1520 mL | 0.7600 mL | 1.5201 mL | 3.8001 mL |
M‑89 Related Classifications
HY-128347 Related Classifications
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