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Cat. No.: HY-115721

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Antimalarial agent 2

Antimalarial agent 2 is a novel orally efficacious antimalarials that suggests a fast in vitro killing profile.

For research use only. We do not sell to patients.

CAS No.: 2829950-49-2
Formula: C₂₇H₂₅N₃O₅
Molecular Weight:471.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Antimalarial agent 2 Chemical Structure

CAS No.: 2829950-49-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Antimalarial agent 2 is a novel orally efficacious antimalarials that suggests a fast in vitro killing profile.

IC₅₀ & Target

Plasmodium

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	>40 μM Compound: 19f	Cytotoxicity against human HEK293 cells assessed as cell viability incubated for 72 hrs by Alamar blue assay Cytotoxicity against human HEK293 cells assessed as cell viability incubated for 72 hrs by Alamar blue assay	[PMID: 34437804]

Chemical Information

CAS No. 2829950-49-2
Molecular Weight 471.50
Formula C₂₇H₂₅N₃O₅
SMILES

O=C(O)C1=CC=C(COCC2=CC=CC(N=C(C(NCC3=CC=CC(CC)=C3)=O)N4)=C2C4=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Laleu B, et al. Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials. J Med Chem. 2021 Sep 9;64(17):12582-12602. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Antimalarial agent 2

All Parasite Isoforms