Cyclic AMP
Based on 30 publication(s) in Google Scholar
Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 60-92-4
- Formula: C10H12N5O6P
- Molecular Weight:329.21
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Publications Citing Use of MedChemExpress (MCE) Cyclic AMP
More- Immunity. 2025 Mar 21:S1074-7613(25)00093-7. [Abstract]
- Cell Stem Cell. 2026 May 15:S1934-5909(26)00158-X. [Abstract]
- Nat Neurosci. 2022 Jun;25(6):805-817. [Abstract]
- Cell Host Microbe. 2026 Mar 11;34(3):494-508.e7. [Abstract]
- Nat Protoc. 2023 Jun;18(6):1930-1957. [Abstract]
- Adv Sci (Weinh). 2025 May 14:e2500566. [Abstract]
- Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
- Biomaterials. 2025 Mar:314:122873. [Abstract]
- Mater Today Bio. 2026 Mar 3:37:102985. [Abstract]
- Cancer Lett. 2025 Sep 29:634:218069. [Abstract]
- Dev Cell. 2025 Sep 3:S1534-5807(25)00530-1. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- J Environ Sci. 2026 Jun 25.
- Talanta. 2024 Jan 15:267:125171. [Abstract]
- Chem Biol Interact. 2026 Jul 25:435:112138. [Abstract]
- Cells. 2024 Nov 2;13(21):1811. [Abstract]
- Genes Immun. 2026 Mar 10. [Abstract]
- Exp Neurol. 2026 Jun 26:115897. [Abstract]
- FEBS J. 2026 Mar 10. [Abstract]
- PLoS Genet. 2026 Jan 23;22(1):e1012013. [Abstract]
- Endocrinology. 2023 Feb 11;164(4):bqad035. [Abstract]
- Arch Biochem Biophys. 2025 Oct:772:110552. [Abstract]
- J Reprod Immunol. 2022 Jun;151:103623. [Abstract]
- J Assist Reprod Genet. 2025 Feb;42(2):665-678. [Abstract]
- Fitoterapia. 2026 Apr:190:107182. [Abstract]
- STAR Protoc. 2026 Mar 20;7(1):104353. [Abstract]
- bioRxiv. 2026 Jan 2:2025.12.31.696910. [Abstract]
- bioRxiv. 2025 Sep 29.
- bioRxiv. 2024 July 27.
- Methods Mol Biol. 2023:2683:103-111. [Abstract]
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RT-PCR
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WB
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RT-PCR
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Cell Imaging/Staining
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ELISA
All Endogenous Metabolite Isoforms
More
Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
Cyclic AMP (Cyclic adenosine monophosphate) modulates mediator generation. Cyclic AMP suppresses the expression of pro-inflammatory cytokines, including TNF-α and IL-12, and enhances the production of the anti-inflammatory cytokine IL-10.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 60-92-4
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Appearance Solid
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Molecular Weight 329.21
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Formula C10H12N5O6P
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Color White to off-white
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP4(O)=O)[C@@H](CO4)O3
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Synonyms
Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; cAMP
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (30)
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Journal Impact Factor
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Most Recent
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Immunity
The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2. [Abstract]2025 Mar 21:S1074-7613(25)00093-7. PMID: 40139186 -
Cell Stem Cell
Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems. [Abstract]2026 May 15:S1934-5909(26)00158-X. PMID: 42143017 -
Nat Neurosci
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations. [Abstract]2022 Jun;25(6):805-817. PMID: 35637371 -
Cell Host Microbe
2026 Mar 11;34(3):494-508.e7. PMID: 41747724 -
Nat Protoc
Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures. [Abstract]2023 Jun;18(6):1930-1957. PMID: 37045994 -
Adv Sci (Weinh)
2025 May 14:e2500566. PMID: 40365742 -
Adv Sci (Weinh)
Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]2024 Sep 4:e2402393. PMID: 39229959
Cyclic AMP purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
After treating KGN cells with 20 μM of cAMP for 24 h, the expression level of KITL significantly increased.
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Biomaterials
LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway. [Abstract]2025 Mar:314:122873. PMID: 39369670 -
Mater Today Bio
Age-mimicking hydrogel stiffness recapitulates the mechanical niche of the hippocampus to regulate neural stem cell senescence. [Abstract]2026 Mar 3:37:102985. PMID: 41852885 -
Cancer Lett
2025 Sep 29:634:218069. PMID: 41033606 -
Dev Cell
A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma. [Abstract]2025 Sep 3:S1534-5807(25)00530-1. PMID: 40930100 -
Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
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Talanta
A simple, rapid and sensitive HILIC LC-MS/MS method for simultaneous determination of 16 purine metabolites in plasma and urine. [Abstract]2024 Jan 15:267:125171. PMID: 37696233 -
Chem Biol Interact
Autophagy attenuates the secondary senescence of endometrial stromal cells induced by Bisphenol S. [Abstract]2026 Jul 25:435:112138. PMID: 42114668 -
Cells
Proof-of-Concept for Long-Term Human Endometrial Epithelial Organoids in Modeling Menstrual Cycle Responses. [Abstract]2024 Nov 2;13(21):1811. PMID: 39513919
Cyclic AMP purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811. [Abstract]
Cyclic AMP (0.5 mM; 14 days) treatment following estrogen (E2) treatment from day 14 onwards in hEOs was measured by quantitative polymerase chain reaction (qPCR).
Cyclic AMP purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811. [Abstract]
Cyclic AMP (0.5 mM; 14 days). Representative immunofluorescent images showing ESR1 (ER), PGR (PR), and PAEP expression at day 21 and 28 through 28-day treatment in hEOs were obtained.
Cyclic AMP purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811. [Abstract]
Cyclic AMP (0.5 mM; 14 days). Violin plot of ELISA for secreted PAEP (left) and SPP1 (right) from culture supernatant with different hormone treatments at day 21 in hEOs was shown.
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Genes Immun
MTA1-mediated transcriptional repression of Cox2 confers resistance against neutrophil infiltration in endometritis. [Abstract]2026 Mar 10. PMID: 41807815 -
Exp Neurol
Roles of astrocytic Connexin 43 gap junctional deficit in alpha-synucleinopathy and inflammation relevant to Parkinson's. [Abstract]2026 Jun 26:115897. PMID: 42362037 -
FEBS J
2026 Mar 10. PMID: 41804674 -
PLoS Genet
A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype. [Abstract]2026 Jan 23;22(1):e1012013. PMID: 41575937 -
Endocrinology
2023 Feb 11;164(4):bqad035. PMID: 36825874 -
Arch Biochem Biophys
TET3 inhibits the decidualization of human endometrial stromal cells by regulating ITGA10 transcription through recruiting HDAC1/2. [Abstract]2025 Oct:772:110552. PMID: 40675525 -
J Reprod Immunol
2022 Jun;151:103623. PMID: 35430461 -
J Assist Reprod Genet
FXYD1 was identified as a hub gene in recurrent miscarriage and involved in decidualization via regulating Na/K-ATPase activity. [Abstract]2025 Feb;42(2):665-678. PMID: 39730944
Cyclic AMP purchased from MedChemExpress. Usage Cited in: J Assist Reprod Genet. 2025 Feb;42(2):665-678. [Abstract]
Cyclic AMP (0.5 mM; 4 days). The FOXO1 mRNA expression in T-HESCs transfected with either control vector or FXYD1-overexpression plasmids at 0, 2, and 4 days during decidualization was measured.
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Fitoterapia
The stem-derived bioactive fraction of Syringa oblata Lindl. Ameliorates insomnia via cAMP signaling-mediated regulation of neurotransmission, oxidative stress, and inflammation: A multi-omics study. [Abstract]2026 Apr:190:107182. PMID: 41861857 -
STAR Protoc
Protocol to identify the signaling network of nucleotide second messengers in Shigella sonnei. [Abstract]2026 Mar 20;7(1):104353. PMID: 41671092 -
bioRxiv
2026 Jan 2:2025.12.31.696910. PMID: 41509464 -
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Methods Mol Biol
Characterizing the Neuron-Glial Interactions by the Co-cultures of Human iPSC-Derived Oligodendroglia and Neurons. [Abstract]2023:2683:103-111. PMID: 37300770
Solvent & Solubility
0.1 M NaOH : 50 mg/mL (151.88 mM; ultrasonic and adjust pH to 6 with NaOH)
H2O : 2 mg/mL (6.08 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
[1]. G M Fimia, et al. Cyclic AMP signaling. J Cell Sci. 2001 Jun;114(Pt 11):1971-2. [Content Brief]
[2]. Paolo Sassone-Corsi, et al. The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a011148. [Content Brief]
[3]. Aronoff DM, et, al. Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res. 2006 Nov;26(11):827-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 0.1 M NaOH | 1 mM | 3.0376 mL | 15.1879 mL | 30.3757 mL | 75.9394 mL |
| 5 mM | 0.6075 mL | 3.0376 mL | 6.0751 mL | 15.1879 mL | |
| 0.1 M NaOH | 10 mM | 0.3038 mL | 1.5188 mL | 3.0376 mL | 7.5939 mL |
| 15 mM | 0.2025 mL | 1.0125 mL | 2.0250 mL | 5.0626 mL | |
| 20 mM | 0.1519 mL | 0.7594 mL | 1.5188 mL | 3.7970 mL | |
| 25 mM | 0.1215 mL | 0.6075 mL | 1.2150 mL | 3.0376 mL | |
| 30 mM | 0.1013 mL | 0.5063 mL | 1.0125 mL | 2.5313 mL | |
| 40 mM | 0.0759 mL | 0.3797 mL | 0.7594 mL | 1.8985 mL | |
| 50 mM | 0.0608 mL | 0.3038 mL | 0.6075 mL | 1.5188 mL | |
| 60 mM | 0.0506 mL | 0.2531 mL | 0.5063 mL | 1.2657 mL | |
| 80 mM | 0.0380 mL | 0.1898 mL | 0.3797 mL | 0.9492 mL | |
| 100 mM | 0.0304 mL | 0.1519 mL | 0.3038 mL | 0.7594 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.