MMAD-d8
Based on 1 Customer Validation
MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.95%
- Fòrmula: C41H58D8N6O6S
- Peso molecular:779.11
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Auristatin |
MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 203849-91-6
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Appearance Solid
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Peso molecular 779.11
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Fòrmula C41H58D8N6O6S
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Color White to off-white
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SMILES
O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@@H](OC)[C@H]3N(C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])NC([C@H](C(C)C)NC)=O)=O)C)=O)CCC3
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Synonyms
Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (128.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2835 mL | 6.4176 mL | 12.8352 mL | 32.0879 mL |
| 5 mM | 0.2567 mL | 1.2835 mL | 2.5670 mL | 6.4176 mL | |
| 10 mM | 0.1284 mL | 0.6418 mL | 1.2835 mL | 3.2088 mL | |
| 15 mM | 0.0856 mL | 0.4278 mL | 0.8557 mL | 2.1392 mL | |
| 20 mM | 0.0642 mL | 0.3209 mL | 0.6418 mL | 1.6044 mL | |
| 25 mM | 0.0513 mL | 0.2567 mL | 0.5134 mL | 1.2835 mL | |
| 30 mM | 0.0428 mL | 0.2139 mL | 0.4278 mL | 1.0696 mL | |
| 40 mM | 0.0321 mL | 0.1604 mL | 0.3209 mL | 0.8022 mL | |
| 50 mM | 0.0257 mL | 0.1284 mL | 0.2567 mL | 0.6418 mL | |
| 60 mM | 0.0214 mL | 0.1070 mL | 0.2139 mL | 0.5348 mL | |
| 80 mM | 0.0160 mL | 0.0802 mL | 0.1604 mL | 0.4011 mL | |
| 100 mM | 0.0128 mL | 0.0642 mL | 0.1284 mL | 0.3209 mL |
MMAD-d8 Related Classifications
HY-15581S Related Classifications
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