Gallamine Triethiodide
Based on 1 Customer Validation
Gallamine Triethiodide is a blood-brain barrier-permeable skeletal muscle relaxant. Gallamine Triethiodide induces skeletal muscle paralysis by blocking acetylcholine. Gallamine Triethiodide directly stimulates intracardiac β receptors. Gallamine Triethiodide prolongs the duration of afterdischarge in the cat cerebral cortex. Gallamine Triethiodide can be used in studies related to convulsive disorders.
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- Pureza: 99.56%
- No. CAS: 65-29-2
- Fòrmula: C30H60I3N3O3
- Peso molecular:891.53
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Actividad biológica
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β-adrenoceptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Domestic cats (2.5 to 5 kg, both sexes, with permanently implanted platinum electrodes over the pial surface of the suprasylvian gyrus)[2]
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Dosage:6.25 mg/kg (single dose); 12.5 mg/kg (repeated heavy doses in a separate animal)
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Administration:i.v.; single dose; repeated heavy doses (separate animal)
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Result:Increased cortical afterdischarge duration to a statistically significant level (0.1% level, Mann-Whitney U test) at 10 to 20 minutes post-administration, peaked within 0.5 to 1 hour, and outlasted recovery from paralysis by up to 1 hour.
Increased average cortical afterdischarge duration from 4 seconds to 180 seconds in immobilized cats.
Induced a similar increase in afterdischarge duration with a second 6.25 mg/kg i.v. dose in one animal.
Induced a generalized electrographic seizure lasting 6 minutes with repeated 12.5 mg/kg i.v. doses.
Showed no consistent changes in expiratory carbon dioxide, blood pressure, body temperature, blood glucose, or direct cortical response to brief single stimuli correlated with increased afterdischarge duration.
Chemical Information
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No. CAS 65-29-2
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Appearance Solid
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Peso molecular 891.53
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Fòrmula C30H60I3N3O3
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Color White to yellow
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SMILES
CC[N+](CC)(CC)CCOC(C(OCC[N+](CC)(CC)CC)=CC=C1)=C1OCC[N+](CC)(CC)CC.[I-].[I-].[I-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
H2O : ≥ 30 mg/mL (33.65 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (56.08 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
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- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.1217 mL | 5.6083 mL | 11.2167 mL | 28.0417 mL |
| 5 mM | 0.2243 mL | 1.1217 mL | 2.2433 mL | 5.6083 mL | |
| 10 mM | 0.1122 mL | 0.5608 mL | 1.1217 mL | 2.8042 mL | |
| 15 mM | 0.0748 mL | 0.3739 mL | 0.7478 mL | 1.8694 mL | |
| 20 mM | 0.0561 mL | 0.2804 mL | 0.5608 mL | 1.4021 mL | |
| 25 mM | 0.0449 mL | 0.2243 mL | 0.4487 mL | 1.1217 mL | |
| 30 mM | 0.0374 mL | 0.1869 mL | 0.3739 mL | 0.9347 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Gallamine Triethiodide Related Classifications
HY-B0416 Related Classifications
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- Gallamine Triethiodide
- 65-29-2
- mAChR
- Adrenergic Receptor
- muscle end-plate acetylcholine receptors
- skeletal muscle paralysis
- convulsive disorders
- intracardiac β receptors
- blood-brain barrier
- acetylcholine
- muscarinic acetylcholine receptors
- post-ganglionic vagal nerve endings
- cat retinal ganglion cell
- skeletal muscle relaxant
- Inhibitor
- inhibitor
- inhibit