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Referencia número: HY-111068

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KD-3010

Name: KD-3010
Brand: MedChemExpress
SKU: HY-111068
Price: 820.00 USD
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1 Cited Publications

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KD-3010 is a potent, orally active, and selective PPARδ agonist.

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No. CAS: 934760-92-6
Fòrmula: C₃₀H₃₃F₃N₂O₈S₂
Peso molecular:670.72

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

KD-3010 Chemical Structure

No. CAS: 934760-92-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

KD-3010 is a potent, orally active, and selective PPARδ agonist.

IC₅₀ & Target

^[1]

PPARδ

Ver todos los productos específicos de isoformas PPAR :

In Vivo

To determine whether PPARδ agonists are beneficial in experimental liver fibrosis, mice are treated orally with a PPARδ agonist, KD-3010, or with the well-validated PPARδ agonist GW501516. KD-3010, but not GW501516, shows hepatoprotective and antifibrotic effects in liver fibrosis induced by carbon tetrachloride (CCl₄) or bile duct ligation (BDL). Liver injury is induced by repeated injections of CCl₄, and mice are treated daily with vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 by oral gavage. Control oil-injected mice do not show any liver damage. Liver injury consisting of hepatocyte death and inflammation is seen in the vehicle- or GW501516-treated group injected with CCl₄ on H&E-stained liver sections but is markedly reduced in the KD3010-treated group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 934760-92-6
Peso molecular 670.72
Fòrmula C₃₀H₃₃F₃N₂O₈S₂
SMILES

O=C([C@H]1CC2=C(C(S(=O)(N3[C@H](C)CN(C4=CC=C(OC(F)(F)F)C=C4)C[C@@H]3C)=O)=CC=C2)C1)O.OS(=O)(C5=CC=C(C)C=C5)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Biomed Pharmacother

Neonatal sevoflurane exposure disrupted fatty acids metabolism, leading to hypomyelination and neurological impairments. [Abstract]

2025 Oct:191:118495. PMID: 40925233

Protocolo

Animal Administration^[1]

Mice^[1]
Male 11-wk-old C57/B6 mice are treated with CCl₄ (2 μL/g body weight; 1:4 dilution with corn oil) or with corn oil as control (2 μL/g body weight) by i.p. injection every third day. Injections are repeated for a total of 12 times. Mice are injected i.p. 12 times with oil as control (n=4 in each group) or with CCl₄ and are administered vehicle (n=14), GW501516 (2 mg/kg; n=12), or KD3010 (10 mg/kg; n=11) daily by oral gavage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Iwaisako K, et al. Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1369-76. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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KD-3010

1 Cited Publications

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KD-3010

Publications Citing Use of MedChemExpress (MCE) KD-3010

Ver todos los productos específicos de isoformas PPAR