L 888607
Based on 1 publication(s) in Google Scholar
L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite.
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- Pureza: 99.87%
- No. CAS: 860033-06-3
- Fòrmula: C19H15ClFNO2S
- Peso molecular:375.84
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L 888607
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Actividad biológica
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DP 0.8 nM (Ki) |
TP Receptor 283 nM (Ki) |
FP Receptor 10018 nM (Ki) |
IP Receptor 14434 nM (Ki) |
L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM[1].
L 888607 has some affinity for the human DP receptor with a Ki value of 211 nM[1].
L 888607 displays a relatively high selectivity for CRTH2 receptor[1].
L 888607 has agonistic activity on recombinant and endogenously expressed CRTH2 receptor with an EC50 value of 0.4 nM[1].
L 888607(100 nM, 20 min) stimulates eosinophil chemotaxis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human eosinophils
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Concentration:100 nM
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Incubation Time:20 min
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Result:Significantly stimulated the migration of eosinophils to the bottom chamber.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male (ICR)BR mice[1]
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Dosage:5 mg/kg, 20 mg/kg
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Administration:i.v., 5 mg/kg, single or oral, 20 mg/kg, single
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Result:Showed no obvious side effect.
Chemical Information
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No. CAS 860033-06-3
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Appearance Solid
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Peso molecular 375.84
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Fòrmula C19H15ClFNO2S
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Color Light yellow to yellow
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SMILES
O=C(O)C[C@@H]1CCN2C1=C(SC3=CC=C(Cl)C=C3)C4=C2C=C(F)C=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
2023 Dec 7;186(25):5500-5516.e21. PMID: 38016470
Solvente y solubilidad
DMSO : 100 mg/mL (266.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6607 mL | 13.3035 mL | 26.6071 mL | 66.5177 mL |
| 5 mM | 0.5321 mL | 2.6607 mL | 5.3214 mL | 13.3035 mL | |
| 10 mM | 0.2661 mL | 1.3304 mL | 2.6607 mL | 6.6518 mL | |
| 15 mM | 0.1774 mL | 0.8869 mL | 1.7738 mL | 4.4345 mL | |
| 20 mM | 0.1330 mL | 0.6652 mL | 1.3304 mL | 3.3259 mL | |
| 25 mM | 0.1064 mL | 0.5321 mL | 1.0643 mL | 2.6607 mL | |
| 30 mM | 0.0887 mL | 0.4435 mL | 0.8869 mL | 2.2173 mL | |
| 40 mM | 0.0665 mL | 0.3326 mL | 0.6652 mL | 1.6629 mL | |
| 50 mM | 0.0532 mL | 0.2661 mL | 0.5321 mL | 1.3304 mL | |
| 60 mM | 0.0443 mL | 0.2217 mL | 0.4435 mL | 1.1086 mL | |
| 80 mM | 0.0333 mL | 0.1663 mL | 0.3326 mL | 0.8315 mL | |
| 100 mM | 0.0266 mL | 0.1330 mL | 0.2661 mL | 0.6652 mL |
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