Referencia número: HY-113486

Lathosterol

2 Cited Publications

Revisión del cliente

Based on 2 publication(s) in Google Scholar

Lathosterol is a plant sterol and cholesterol-like molecule. Lathosterol increases antioxidant enzymes (such as SOD, CAT, and GSH) and decreases LDH. Lathosterol has a hepatoprotective effect on mice with acetaminophen (HY-66005)-induced liver injury^[1].

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Pureza: 99.96%
No. CAS: 80-99-9
Fòrmula: C₂₇H₄₆O
Peso molecular:386.65

Almacenamiento:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lathosterol Chemical Structure

No. CAS: 80-99-9

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (2)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

Human Endogenous Metabolite

Ver todos los productos específicos de isoformas Endogenous Metabolite :

In Vivo

Lathosterol (25-50 μg/kg; i.p.; 7 days) shows hepatoprotective effects in the mouse model of Acetaminophen (HY-66005)-induced hepatotoxicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino mice (either sex, 22-30 g in weight, 8-12 weeks old) + Acetaminophen (HY-66005)-induced hepatotoxicity model^[2]
Dosage:

25 μg/kg BW, 50 μg/kg BW (dissolved in DMSO, final concentration adjusted to 0.1% DMSO solution with distilled water)
Administration:

Intraperitoneal injection (i.p.), 7 days
Result:

Reduced the levels of ALT, AST, ALP, LDH and direct bilirubin in serum.
Increased the enzyme concentrations of SOD, CAT and GSH in liver homogenate.
Improved the histological changes of the liver (only minor bleeding was observed at 50 μg/kg BW).

Chemical Information

No. CAS 80-99-9
Appearance Solid
Peso molecular 386.65
Fòrmula C₂₇H₄₆O
Color White to off-white
SMILES

CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C3=CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (2)

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Journal Impact Factor

Cell Death Dis

Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis. [Abstract]

2023 Nov 14;14(11):740. PMID: 37963874
Research Square Preprint

2023 Jun 22.

Solvente y solubilidad

In Vitro:

Ethanol : 25 mg/mL (64.66 mM; Need ultrasonic)

DMSO : 2 mg/mL (5.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5863 mL

12.9316 mL

25.8632 mL

5 mM

0.5173 mL

2.5863 mL

5.1726 mL

10 mM

0.2586 mL

1.2932 mL

2.5863 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2 mg/mL (5.17 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 2 mg/mL (5.17 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kempen HJ, et al. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J Lipid Res. 1988 Sep;29(9):1149-55. [Content Brief]

[2]. Ullah H, et al. Lophenol and lathosterol from resin of Commiphora kua possess hepatoprotective effects in vivo. J Ethnopharmacol. 2020 Apr 24;252:112558. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	2.5863 mL	12.9316 mL	25.8632 mL	64.6580 mL
DMSO / Ethanol	5 mM	0.5173 mL	2.5863 mL	5.1726 mL	12.9316 mL
Ethanol	10 mM	0.2586 mL	1.2932 mL	2.5863 mL	6.4658 mL
	15 mM	0.1724 mL	0.8621 mL	1.7242 mL	4.3105 mL
	20 mM	0.1293 mL	0.6466 mL	1.2932 mL	3.2329 mL
	25 mM	0.1035 mL	0.5173 mL	1.0345 mL	2.5863 mL
	30 mM	0.0862 mL	0.4311 mL	0.8621 mL	2.1553 mL
	40 mM	0.0647 mL	0.3233 mL	0.6466 mL	1.6164 mL
	50 mM	0.0517 mL	0.2586 mL	0.5173 mL	1.2932 mL
	60 mM	0.0431 mL	0.2155 mL	0.4311 mL	1.0776 mL

Keywords

Lathosterol

2 Cited Publications

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Lathosterol

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Publications Citing Use of MedChemExpress (MCE) Lathosterol

Ver todos los productos específicos de isoformas Endogenous Metabolite

Actividad biológica

Chemical Information

Publications (2)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Lathosterol Related Classifications

HY-113486 Related Classifications