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OTSSP167

(Synonyms: OTS167)
23 Cited Publications
Revisión del cliente

Based on 23 publication(s) in Google Scholar

OTSSP167 (OTS167) is a highly potent and ATP-competitive MELK inhibitor with IC50 value of 0.41 nM.

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  • Pureza: 99.27%
  • No. CAS: 1431697-89-0
  • Fòrmula: C25H28Cl2N4O2
  • Peso molecular:487.42
  • Almacenamiento:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • OTSSP167 Chemical Structure
    OTSSP167 Chemical Structure
  • Experimental Validation Results for OTSSP167
  • Experimental Validation Results for OTSSP167
  • Experimental Validation Results for OTSSP167
  • Experimental Validation Results for OTSSP167
  • Experimental Validation Results for OTSSP167
  • Experimental Validation Results for OTSSP167
  • Experimental Validation Results for OTSSP167
  • Experimental Validation Results for OTSSP167
  • Experimental Validation Results for OTSSP167
No. CAS: 1431697-89-0
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • OTSSP167 Chemical Structure
    OTSSP167 Chemical Structure
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    OTSSP167 purchased from MedChemExpress. Usage Cited in: Blood Cancer J. 2019 Nov 18;9(12):87. [Abstract]

    Customer Validation
     Expression of MELK and Aurora B kinase (AurB) is determined in samples from vehicle and OTSSP167-treated mice. β-actin is used as loading control.

  • 1/16

    OTSSP167 purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2018 Nov 15;24(22):5645-5657. [Abstract]

    Customer Validation
     Western blot showing protein levels of MELK, PPARγ and phospho-PPARγS112 in JHH-DIPG-01, HSJD-DIPG-12, SF7761 and HSJD-DIPG-07 cells after 48 hours treatment with either 20 nM or 50 nM OTSSP167.

  • 1/16

    OTSSP167 purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2018 Mar;10(3). pii: e8274. [Abstract]

    Customer Validation
     Validation of effects of OTS167 on phosphorylation of p90RSK and its targets. C4-2b cells are treated with vehicle or 30 nM OTS167 for the indicated times, and levels of total and phosphorylated proteins are determined by Western blot analysis. β-Actin is used as a loading control.

  • 1/16

    OTSSP167 purchased from MedChemExpress. Usage Cited in: Gynecol Oncol. 2017 Apr;145(1):159-166. [Abstract]

    Customer Validation
     Western blotting demonstrates that 100 nM OTSSP167 for 48 h produces marked PARP-1 cleavage in HGSOC cell lines whereas no or weak PARP-1 cleavage is observed in normal ovarian surface epithelial cells (HOSE6-3) and in the fallopian tubal cells (FT33-tag, FT190, FT237).

  • 1/16

    OTSSP167 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2017 Feb 14;7:42502. [Abstract]

    Customer Validation
     In vitro kinase assays are performed using MPK38 immunoprecipitates, which are obtained from cell lysates of wild-type and clonal CRISPR/Cas9 ZPR9 (T252A) KI isolates, treated with (+) or without (−) OTSSP167 (1 μM, 2 h), a MPK38-specific inhibitor, in the presence of ZPR9 immunoprecipitates as the substrate. Recombinant MPK38 proteins (lower panels), which were expressed in bacterial cells, treated with (+) or without (−) OTSSP167 are also used instead of the MPK38 immunoprecipitates (upper pan

  • 1/16

    OTSSP167 purchased from MedChemExpress. Usage Cited in: PLoS One. 2017 Feb 24;12(2):e0172832. [Abstract]

    Customer Validation
     OTS167 reduces proliferation and regulates MELK transcript but not protein levels in TNBC cells. The MELK 52 kDa variant is highly expressed in the TNBC cell lines but not in luminal A MCF-7.

  • 1/16

    OTSSP167 purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Dec 20;9(2):2591-2602. [Abstract]

    Customer Validation
     Effects of OTSSP167 on PARP and Caspase-3 cleavages in NB cells are shown by immunoblotting assay.

  • 1/16

    OTSSP167 purchased from MedChemExpress. Usage Cited in: Patent. US20160291017A1.

    Customer Validation
     Mitotic MDA-MB-468 cells are treated for 30 min with vehicle or 200 nM OTSSP167, a MELK inhibitor. Lysates are used for immunoblotting.

  • 1/16

    OTSSP167 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2014 May 4;13:100. [Abstract]

    Customer Validation
     MELK specific inhibitor OTSSP167 suppresses cell migration and invasion. A, Immunoblotting representing MELK expression in SGC7901 cell following OTSSP167 treatment for indicated period. In the upper panel, SGC7901 cell are treated with different concentration (0, 0.1, 1 μM) of OTSSP167 for 1 h and 2 h. In the lower panel, SGC7901/vector and SGC7901/MELK cell are treated with 1 μM OTSSP167 for 2 h. C, SGC7901/vector and SGC7901/MELK cells are treated with 1 μM OTSSP167 for indicated period and

  • OTSSP167