Sotirimod
Based on 1 Customer Validation
Sotirimod (R850) is a TLR7 agonist and immunomodulator. Sotirimod inhibits Apoptosis. Sotirimod is applicable to research related to actinic keratosis, early cervical HPV infection, and precancerous lesions of colorectal cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.90%
- No. CAS: 227318-75-4
- Fòrmula: C14H17N5
- Peso molecular:255.32
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
TLR7 |
In Vitro
Chemical Information
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No. CAS 227318-75-4
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Appearance Solid
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Peso molecular 255.32
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Fòrmula C14H17N5
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Color White to off-white
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SMILES
NC1=NC2=CC=CN=C2C3=C1N=C(C)N3CC(C)C
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Synonyms
R850
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (97.92 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.9167 mL | 19.5833 mL | 39.1665 mL | 97.9163 mL |
| 5 mM | 0.7833 mL | 3.9167 mL | 7.8333 mL | 19.5833 mL | |
| 10 mM | 0.3917 mL | 1.9583 mL | 3.9167 mL | 9.7916 mL | |
| 15 mM | 0.2611 mL | 1.3056 mL | 2.6111 mL | 6.5278 mL | |
| 20 mM | 0.1958 mL | 0.9792 mL | 1.9583 mL | 4.8958 mL | |
| 25 mM | 0.1567 mL | 0.7833 mL | 1.5667 mL | 3.9167 mL | |
| 30 mM | 0.1306 mL | 0.6528 mL | 1.3056 mL | 3.2639 mL | |
| 40 mM | 0.0979 mL | 0.4896 mL | 0.9792 mL | 2.4479 mL | |
| 50 mM | 0.0783 mL | 0.3917 mL | 0.7833 mL | 1.9583 mL | |
| 60 mM | 0.0653 mL | 0.3264 mL | 0.6528 mL | 1.6319 mL | |
| 80 mM | 0.0490 mL | 0.2448 mL | 0.4896 mL | 1.2240 mL |
Sotirimod Related Classifications
HY-101589 Related Classifications
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Keywords
- Sotirimod
- 227318-75-4
- R850
- R 850
- R-850
- Toll-like Receptor (TLR)
- Apoptosis
- gastrointestinal epithelial cells
- TLR7
- actinic keratoses
- colorectal polyps/polyposis
- precancerous colorectal changes
- early cervical HPV infections
- precancerous gastrointestinal cells
- colorectal cancer
- malignant colorectal tumour cells
- Inhibitor
- inhibitor
- inhibit